TELENZEPINE


SMILES Cc1scc2c1N(C(=O)CN1CCN(C)CC1)c1ccccc1NC2=O
InChIKey VSWPGAIWKHPTKX-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 2
Molecular weight (Da) 370.1

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
M4 ACM4 Rat Acetylcholine (muscarinic) A pKi 7.76 7.76 7.76 ChEMBL
M3 ACM3 Rat Acetylcholine (muscarinic) A pKi 8.16 8.16 8.16 ChEMBL
M2 ACM2 Rat Acetylcholine (muscarinic) A pKi 7.3 7.3 7.3 ChEMBL
M1 ACM1 Rat Acetylcholine (muscarinic) A pKi 8.74 8.74 8.74 ChEMBL
M4 ACM4 Human Acetylcholine (muscarinic) A pKi 7.9 8.24 8.58 PDSP Ki database
M4 ACM4 Rat Acetylcholine (muscarinic) A pKi 7.17 7.17 7.17 PDSP Ki database
M2 ACM2 Rat Acetylcholine (muscarinic) A pKi 7.77 7.77 7.77 PDSP Ki database
M1 ACM1 Rat Acetylcholine (muscarinic) A pKi 8.89 8.89 8.89 PDSP Ki database
M4 ACM4 Chicken Acetylcholine (muscarinic) A pKi 8.61 8.61 8.61 PDSP Ki database
M3 ACM3 Rat Acetylcholine (muscarinic) A pKi 8.12 8.12 8.12 PDSP Ki database
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
M1 ACM1 Rat Acetylcholine (muscarinic) A Potency 7.5 7.53 7.55 ChEMBL
TSH TSHR Human Glycoprotein hormone A Potency 5.1 5.1 5.1 ChEMBL