Biased Signaling Atlas

RS 39604

SMILES	COc1cc(N)c(cc1C(=O)OCCCN1CCCCC1)Cl
InChIKey	RLSGBCUXLRMTPF-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors	5
Hydrogen bond donors	1
Rotatable bonds	6
Molecular weight (Da)	326.1

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	No

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids GPCRdb

Bioactivities

Affinity
Potency

Receptor					Activity				Source
GTP	Uniprot	Species	Family	Class	Type	Min	Avg	Max	Database
5-HT₄	5HT4R	Human	5-Hydroxytryptamine	A	pKi	8.2	8.45	8.7	Guide to Pharmacology
5-HT₄	5HT4R	Rat	5-Hydroxytryptamine	A	pKi	7.55	7.55	7.55	ChEMBL
5-HT₄	5HT4R	Human	5-Hydroxytryptamine	A	pKi	7.5	7.5	7.5	ChEMBL
5-HT₄	5HT4R	Guinea pig	5-Hydroxytryptamine	A	pKi	7.72	7.72	7.72	ChEMBL

Receptor					Activity				Source
GTP	Uniprot	Species	Family	Class	Type	Min	Avg	Max	Database
5-HT₄	5HT4R	Human	5-Hydroxytryptamine	A	pIC50	7.31	7.31	7.31	ChEMBL
5-HT₄	5HT4R	Guinea pig	5-Hydroxytryptamine	A	pEC50	7.52	7.52	7.52	ChEMBL