SB258585


SMILES COc1ccc(cc1N1CCN(CC1)C)NS(=O)(=O)c1ccc(cc1)I
InChIKey BDHMSYNBSBZCAF-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 5
Molecular weight (Da) 487.0

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Ligand site mutations 5-HT6

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT6 5HT6R Human 5-Hydroxytryptamine A pKi 8.53 8.53 8.53 Guide to Pharmacology
5-HT6 5HT6R Mouse 5-Hydroxytryptamine A pKi 6.94 8.21 9.49 ChEMBL
5-HT6 5HT6R Human 5-Hydroxytryptamine A pKi 8.6 8.6 8.6 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT6 5HT6R Human 5-Hydroxytryptamine A pIC50 7.72 7.72 7.72 ChEMBL