SKF-83959


SMILES CN1CCc2c(C(C1)c1cccc(c1)C)cc(c(c2Cl)O)O
InChIKey JXMYTVOBSFOHAF-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 3
Hydrogen bond donors 2
Rotatable bonds 1
Molecular weight (Da) 317.1

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
D1 DRD1 Human Dopamine A pKi 8.71 8.86 8.93 ChEMBL
D3 DRD3 Human Dopamine A pKi 6.4 6.4 6.4 PDSP Ki database
D5 DRD5 Human Dopamine A pKi 8.12 8.12 8.12 PDSP Ki database
5-HT2A 5HT2A Rat 5-Hydroxytryptamine A pKi 6.58 6.58 6.58 PDSP Ki database
D2 DRD2 Rat Dopamine A pKi 6.04 6.04 6.04 PDSP Ki database
D1 DRD1 Rat Dopamine A pKi 8.93 8.93 8.93 PDSP Ki database
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
D1 DRD1 Human Dopamine A pEC50 9.7 9.7 9.7 ChEMBL
D1 DRD1 Human Dopamine A pEC50 9.7 9.7 9.7 Guide to Pharmacology