tizanidine


SMILES Clc1ccc2c(c1NC1=NCCN1)nsn2
InChIKey XFYDIVBRZNQMJC-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 6
Hydrogen bond donors 2
Rotatable bonds 1
Molecular weight (Da) 253.0

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug Yes

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
α2A ADA2A Human Adrenoceptors A pKi 6.0 6.0 6.0 Guide to Pharmacology
α2B ADA2B Human Adrenoceptors A pKi 5.8 5.8 5.8 Guide to Pharmacology
α2A ADA2A Human Adrenoceptors A pKi 7.21 7.21 7.21 PDSP Ki database
α2C ADA2C Human Adrenoceptors A pKi 7.12 7.12 7.12 PDSP Ki database
α2B ADA2B Rat Adrenoceptors A pKi 7.12 7.12 7.12 PDSP Ki database
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
α2A ADA2A Human Adrenoceptors A pEC50 7.1 7.1 7.1 Guide to Pharmacology
α2A ADA2A Human Adrenoceptors A pIC50 7.6 7.6 7.6 Guide to Pharmacology
α2B ADA2B Human Adrenoceptors A pEC50 6.65 6.65 6.65 Guide to Pharmacology
α2B ADA2B Human Adrenoceptors A pIC50 7.8 7.8 7.8 Guide to Pharmacology
α1A ADA1A Bovine Adrenoceptors A pEC50 6.58 6.58 6.58 ChEMBL
α2C ADA2C Human Adrenoceptors A pEC50 5.91 5.91 5.91 ChEMBL
α2A ADA2A Human Adrenoceptors A pEC50 7.07 7.07 7.07 ChEMBL
α2C ADA2C Human Adrenoceptors A pEC50 8.23 8.23 8.23 Drug Central
α2A ADA2A Human Adrenoceptors A pEC50 8.15 8.15 8.15 Drug Central
α1A ADA1A Bovine Adrenoceptors A pEC50 8.18 8.18 8.18 Drug Central