(+)-WAY 100135


SMILES COc1ccccc1N1CCN(CC1)C[C@@H](C(=O)NC(C)(C)C)c1ccccc1
InChIKey UMTDAKAAYOXIKU-HXUWFJFHSA-N

Chemical properties

Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 6
Molecular weight (Da) 395.3

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT1B 5HT1B Human 5-Hydroxytryptamine A pKi 5.8 5.8 5.8 Guide to Pharmacology
5-HT1D 5HT1D Human 5-Hydroxytryptamine A pKi 7.6 7.6 7.6 Guide to Pharmacology
D2 DRD2 Rat Dopamine A pKi 6.41 6.58 6.75 ChEMBL
5-HT1A 5HT1A Rat 5-Hydroxytryptamine A pKi 7.49 7.52 7.55 ChEMBL
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKd 8.9 8.9 8.9 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT1A 5HT1A Rat 5-Hydroxytryptamine A pIC50 7.47 7.7 7.82 ChEMBL
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pIC50 7.77 7.77 7.77 ChEMBL