CLOTHIAPINE


SMILES CN1CCN(C2=Nc3ccccc3Sc3ccc(Cl)cc32)CC1
InChIKey KAAZGXDPUNNEFN-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 4
Hydrogen bond donors 0
Rotatable bonds 0
Molecular weight (Da) 343.1

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
D1 DRD1 Rat Dopamine A pKi 7.85 7.85 7.85 ChEMBL
D2 DRD2 Rat Dopamine A pKi 8.35 8.36 8.36 ChEMBL
D2 DRD2 Human Dopamine A pKi 9.31 9.31 9.31 ChEMBL
5-HT2A 5HT2A Rat 5-Hydroxytryptamine A pKi 8.46 8.46 8.46 PDSP Ki database
5-HT6 5HT6R Rat 5-Hydroxytryptamine A pKi 7.8 7.8 7.8 PDSP Ki database
D2 DRD2 Human Dopamine A pKi 8.03 8.03 8.03 Drug Central
D1 DRD1 Rat Dopamine A pKi 8.11 8.11 8.11 Drug Central
D2 DRD2 Rat Dopamine A pKi 8.08 8.08 8.08 Drug Central
5-HT7 5HT7R Rat 5-Hydroxytryptamine A pKi 8.37 8.37 8.37 PDSP Ki database
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database