CHEMBL3616857


SMILES N[C@@]1(C(=O)O)C[C@H](Sc2nnc(C(F)F)[nH]2)[C@H]2[C@H](C(=O)O)[C@H]21
InChIKey HQTAUDRHEUIJTC-CUQKDWFASA-N

Chemical properties

Hydrogen bond acceptors 6
Hydrogen bond donors 4
Rotatable bonds 5
Molecular weight (Da) 334.1

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
mGlu2 GRM2 Human Metabotropic glutamate C pKi 7.87 7.87 7.87 ChEMBL
mGlu3 GRM3 Human Metabotropic glutamate C pKi 7.24 7.24 7.24 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
mGlu2 GRM2 Human Metabotropic glutamate C pEC50 8.2 8.72 9.24 ChEMBL
mGlu3 GRM3 Human Metabotropic glutamate C pIC50 6.61 6.61 6.61 ChEMBL
mGlu3 GRM3 Human Metabotropic glutamate C pEC50 7.56 7.56 7.56 ChEMBL