cyclizine


SMILES CN1CCN(CC1)C(c1ccccc1)c1ccccc1
InChIKey UVKZSORBKUEBAZ-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 2
Hydrogen bond donors 0
Rotatable bonds 3
Molecular weight (Da) 266.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug Yes

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
H1 HRH1 Human Histamine A pKi 8.35 8.35 8.35 Guide to Pharmacology
α1B ADA1B Rat Adrenoceptors A pKi 5.86 5.86 5.86 ChEMBL
α1D ADA1D Human Adrenoceptors A pKi 6.22 6.22 6.22 ChEMBL
M5 ACM5 Human Acetylcholine (muscarinic) A pKi 6.34 6.34 6.34 ChEMBL
M4 ACM4 Human Acetylcholine (muscarinic) A pKi 6.92 6.92 6.92 ChEMBL
H1 HRH1 Human Histamine A pKi 8.35 8.35 8.35 ChEMBL
M3 ACM3 Human Acetylcholine (muscarinic) A pKi 6.8 6.8 6.8 ChEMBL
α2A ADA2A Human Adrenoceptors A pKi 6.24 6.24 6.24 ChEMBL
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 6.62 6.62 6.62 ChEMBL
M2 ACM2 Human Acetylcholine (muscarinic) A pKi 6.38 6.38 6.38 ChEMBL
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 6.27 6.27 6.27 ChEMBL
M1 ACM1 Human Acetylcholine (muscarinic) A pKi 6.79 6.79 6.79 ChEMBL
D3 DRD3 Human Dopamine A pKi 5.99 5.99 5.99 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 7.19 7.19 7.19 ChEMBL
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 8.18 8.18 8.18 Drug Central
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 8.2 8.2 8.2 Drug Central
M1 ACM1 Human Acetylcholine (muscarinic) A pKi 8.17 8.17 8.17 Drug Central
M2 ACM2 Human Acetylcholine (muscarinic) A pKi 8.19 8.19 8.19 Drug Central
M3 ACM3 Human Acetylcholine (muscarinic) A pKi 8.17 8.17 8.17 Drug Central
M4 ACM4 Human Acetylcholine (muscarinic) A pKi 8.16 8.16 8.16 Drug Central
M5 ACM5 Human Acetylcholine (muscarinic) A pKi 8.2 8.2 8.2 Drug Central
α1D ADA1D Human Adrenoceptors A pKi 8.21 8.21 8.21 Drug Central
D3 DRD3 Human Dopamine A pKi 8.22 8.22 8.22 Drug Central
H1 HRH1 Human Histamine A pKi 8.08 8.08 8.08 Drug Central
α1B ADA1B Rat Adrenoceptors A pKi 8.23 8.23 8.23 Drug Central
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 8.14 8.14 8.14 Drug Central
α2A ADA2A Human Adrenoceptors A pKi 8.21 8.21 8.21 Drug Central
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
α1B ADA1B Rat Adrenoceptors A pIC50 5.6 5.6 5.6 ChEMBL
α1D ADA1D Human Adrenoceptors A pIC50 5.92 5.92 5.92 ChEMBL
M5 ACM5 Human Acetylcholine (muscarinic) A pIC50 6.2 6.2 6.2 ChEMBL
M4 ACM4 Human Acetylcholine (muscarinic) A pIC50 6.07 6.07 6.07 ChEMBL
H1 HRH1 Human Histamine A pIC50 7.42 7.42 7.42 ChEMBL
M3 ACM3 Human Acetylcholine (muscarinic) A pIC50 6.13 6.13 6.13 ChEMBL
α2A ADA2A Human Adrenoceptors A pIC50 5.81 5.81 5.81 ChEMBL
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pIC50 6.43 6.43 6.43 ChEMBL
M2 ACM2 Human Acetylcholine (muscarinic) A pIC50 5.94 5.94 5.94 ChEMBL
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pIC50 5.99 5.99 5.99 ChEMBL
M1 ACM1 Human Acetylcholine (muscarinic) A pIC50 6.17 6.17 6.17 ChEMBL
D3 DRD3 Human Dopamine A pIC50 5.52 5.52 5.52 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pIC50 6.65 6.65 6.65 ChEMBL