CHEMBL3613878


SMILES Clc1cccc(N2CCN(CCc3cn(-c4ccn5nccc5c4)nn3)CC2)c1Cl
InChIKey HMVJSLZLZZJKHU-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 7
Hydrogen bond donors 0
Rotatable bonds 5
Molecular weight (Da) 441.1

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
D4 DRD4 Human Dopamine A pKi 6.75 6.75 6.75 ChEMBL
D1 DRD1 Human Dopamine A pKi 6.92 6.92 6.92 ChEMBL
D3 DRD3 Human Dopamine A pKi 8.66 8.66 8.66 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 8.15 8.15 8.15 ChEMBL
D2 DRD2 Human Dopamine A pKi 7.66 7.83 8.0 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
D2 DRD2 Human Dopamine A pEC50 5.96 6.14 6.32 ChEMBL