CHEMBL3634015


SMILES Cc1n[nH]c(C)c1[C@H](C)NC(=O)COc1cc(C(F)(F)F)c2c(-c3ccccc3)nn(C)c2n1
InChIKey KNSSBXCHRPNPDS-LBPRGKRZSA-N

Chemical properties

Hydrogen bond acceptors 6
Hydrogen bond donors 2
Rotatable bonds 6
Molecular weight (Da) 472.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
OX1 OX1R Human Orexin A pKi 8.3 8.41 8.52 ChEMBL
OX1 OX1R Human Orexin A pKd 6.38 7.45 8.52 ChEMBL
OX2 OX2R Human Orexin A pKi 8.1 8.4 8.7 ChEMBL
OX2 OX2R Human Orexin A pKd 6.84 7.47 8.1 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database