CHEMBL369310


SMILES Cc1nc(C#Cc2ccc(-c3cccnc3)nc2)cs1
InChIKey PTKUANYKLGZFAX-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 4
Hydrogen bond donors 0
Rotatable bonds 1
Molecular weight (Da) 277.1

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
mGlu5 GRM5 Rat Metabotropic glutamate C pKi 7.95 8.32 8.7 ChEMBL
mGlu5 GRM5 Human Metabotropic glutamate C pKi 8.25 8.29 8.33 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
mGlu5 GRM5 Rat Metabotropic glutamate C pIC50 8.28 8.28 8.28 ChEMBL
mGlu5 GRM5 Human Metabotropic glutamate C pIC50 8.21 8.46 8.7 ChEMBL