CHEMBL366904


SMILES O=C(NC/C=C/CN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2o1
InChIKey MPYBYEHRQXVCIP-ONEGZZNKSA-N

Chemical properties

Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 6
Molecular weight (Da) 443.1

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
D4 DRD4 Human Dopamine A pKi 5.97 5.97 5.97 ChEMBL
D1 DRD1 Human Dopamine A pKi 5.84 5.84 5.84 ChEMBL
D3 DRD3 Human Dopamine A pKi 8.15 8.55 8.68 ChEMBL
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 7.23 7.23 7.23 ChEMBL
D2 DRD2 Human Dopamine A pKi 6.88 7.04 7.12 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
D3 DRD3 Human Dopamine A pIC50 7.73 7.73 7.73 ChEMBL
D2 DRD2 Human Dopamine A pIC50 6.96 6.96 6.96 ChEMBL