CHEMBL3669532


SMILES Cc1ccc(N)c(CN2CCCC3(CCN(c4cnc5ccccc5n4)CC3)C2=O)c1
InChIKey MKFWJTCXKSYQBK-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 3
Molecular weight (Da) 415.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
OX1 OX1R Human Orexin A pKi 5.64 5.64 5.64 ChEMBL
OX1 OX1R Human Orexin A pKd 5.3 5.3 5.3 ChEMBL
OX2 OX2R Human Orexin A pKi 6.86 6.86 6.86 ChEMBL
OX2 OX2R Human Orexin A pKd 6.49 6.49 6.49 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database