METHAMPHETAMINE


SMILES CN[C@@H](C)Cc1ccccc1
InChIKey MYWUZJCMWCOHBA-VIFPVBQESA-N

Chemical properties

Hydrogen bond acceptors 1
Hydrogen bond donors 1
Rotatable bonds 3
Molecular weight (Da) 149.1

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
D1 DRD1 Human Dopamine A pKi 5.0 5.0 5.0 PDSP Ki database
D2 DRD2 Human Dopamine A pKi 5.0 5.0 5.0 PDSP Ki database
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 5.0 5.0 5.0 PDSP Ki database
5-HT2C 5HT2C Rat 5-Hydroxytryptamine A pKi 5.0 5.0 5.0 PDSP Ki database
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 5.0 5.0 5.0 PDSP Ki database
α2A ADA2A Human Adrenoceptors A pKi 5.38 5.38 5.38 PDSP Ki database
α2B ADA2B Human Adrenoceptors A pKi 6.13 6.13 6.13 PDSP Ki database
α2C ADA2C Human Adrenoceptors A pKi 6.09 6.09 6.09 PDSP Ki database
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 8.3 8.3 8.3 Drug Central
α2A ADA2A Human Adrenoceptors A pKi 8.27 8.27 8.27 Drug Central
α2B ADA2B Human Adrenoceptors A pKi 8.21 8.21 8.21 Drug Central
α2C ADA2C Human Adrenoceptors A pKi 8.22 8.22 8.22 Drug Central
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
TA1 TAAR1 Rat Trace amine A pEC50 5.69 6.33 6.88 ChEMBL
TA1 TAAR1 Human Trace amine A pEC50 5.82 5.86 5.89 ChEMBL
TA1 TAAR1 Mouse Trace amine A pEC50 5.74 6.65 7.75 ChEMBL
TA1 TAAR1 Rat Trace amine A pEC50 8.16 8.16 8.16 Drug Central
TA1 TAAR1 Mouse Trace amine A pEC50 8.15 8.15 8.15 Drug Central
TA1 TAAR1 Rhesus macaque Trace amine A pEC50 8.28 8.28 8.28 Drug Central
TA1 TAAR1 Human Trace amine A pEC50 8.23 8.23 8.23 Drug Central
TA1 TAAR1 Rhesus macaque Trace amine A pEC50 5.28 5.28 5.28 ChEMBL