[D-Trp8]γ-MSH
SMILES | None |
InChIKey | GZWUQPQBOGLSIM-VOOUCTBASA-N |
Sequence | YVMGHFRWDRFG |
Chemical properties
Hydrogen bond acceptors | None |
Hydrogen bond donors | None |
Rotatable bonds | None |
Molecular weight (Da) |
Drug properties
Molecular type | Peptide |
Endogenous/Surrogate | Surrogate |
Approved drug | No |
Database connections
Ligand site mutations | MC4 |
Bioactivities
Receptor | Activity | Source | |||||||
---|---|---|---|---|---|---|---|---|---|
GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
MC5 | MC5R | Human | Melanocortin | A | pKi | 5.68 | 5.68 | 5.68 | ChEMBL |
MC3 | MC3R | Human | Melanocortin | A | pKi | 6.16 | 6.16 | 6.16 | ChEMBL |
MC4 | MC4R | Human | Melanocortin | A | pKi | 6.14 | 6.14 | 6.14 | ChEMBL |
Receptor | Activity | Source | |||||||
---|---|---|---|---|---|---|---|---|---|
GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
MC3 | MC3R | Human | Melanocortin | A | pIC50 | 8.2 | 8.2 | 8.2 | Guide to Pharmacology |
MC5 | MC5R | Human | Melanocortin | A | pEC50 | 6.26 | 6.3 | 6.41 | ChEMBL |
MC5 | MC5R | Human | Melanocortin | A | pIC50 | 5.6 | 5.85 | 6.48 | ChEMBL |
MC3 | MC3R | Human | Melanocortin | A | pEC50 | 6.16 | 7.05 | 8.43 | ChEMBL |
MC3 | MC3R | Human | Melanocortin | A | pIC50 | 7.14 | 7.21 | 7.4 | ChEMBL |
MC4 | MC4R | Human | Melanocortin | A | pEC50 | 5.58 | 6.51 | 7.19 | ChEMBL |
MC4 | MC4R | Human | Melanocortin | A | pIC50 | 6.11 | 6.42 | 7.35 | ChEMBL |
MC1 | MSHR | Human | Melanocortin | A | pEC50 | 6.52 | 6.73 | 7.16 | ChEMBL |
MC1 | MSHR | Human | Melanocortin | A | pIC50 | 6.0 | 6.97 | 8.92 | ChEMBL |