CHEMBL391661


SMILES Cc1ccc2c(OCCN3CCC(Cc4cc5c(cc4F)OCC(=O)N5)CC3)cc(Cl)cc2n1
InChIKey GRNSMKAYAMENDT-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 6
Molecular weight (Da) 483.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT1B 5HT1B Human 5-Hydroxytryptamine A pKi 5.7 5.7 5.7 ChEMBL
5-HT1D 5HT1D Human 5-Hydroxytryptamine A pKi 6.1 6.1 6.1 ChEMBL
5-HT7 5HT7R Human 5-Hydroxytryptamine A pKi 7.4 7.4 7.4 ChEMBL
β1 ADRB1 Human Adrenoceptors A pKi 5.6 5.6 5.6 ChEMBL
5-HT6 5HT6R Human 5-Hydroxytryptamine A pKi 5.1 5.1 5.1 ChEMBL
D3 DRD3 Human Dopamine A pKi 5.7 5.7 5.7 ChEMBL
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 8.6 8.6 8.6 ChEMBL
D2 DRD2 Human Dopamine A pKi 5.5 5.5 5.5 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database