flunarizine


SMILES C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F
InChIKey SMANXXCATUTDDT-QPJJXVBHSA-N

Chemical properties

Hydrogen bond acceptors 2
Hydrogen bond donors 0
Rotatable bonds 6
Molecular weight (Da) 404.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug Yes

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
D2 DRD2 Rat Dopamine A pKi 6.95 7.67 8.4 Guide to Pharmacology
α1B ADA1B Rat Adrenoceptors A pKi 6.22 6.22 6.22 ChEMBL
α1A ADA1A Rat Adrenoceptors A pKi 6.36 6.36 6.36 ChEMBL
α1D ADA1D Human Adrenoceptors A pKi 6.27 6.27 6.27 ChEMBL
α2B ADA2B Human Adrenoceptors A pKi 6.06 6.06 6.06 ChEMBL
M5 ACM5 Human Acetylcholine (muscarinic) A pKi 6.1 6.1 6.1 ChEMBL
α2C ADA2C Human Adrenoceptors A pKi 7.5 7.5 7.5 ChEMBL
M4 ACM4 Human Acetylcholine (muscarinic) A pKi 6.1 6.1 6.1 ChEMBL
H1 HRH1 Human Histamine A pKi 7.75 7.75 7.75 ChEMBL
M3 ACM3 Human Acetylcholine (muscarinic) A pKi 6.5 6.5 6.5 ChEMBL
5-HT1A 5HT1A Rat 5-Hydroxytryptamine A pKi 5.61 5.61 5.61 ChEMBL
α2A ADA2A Human Adrenoceptors A pKi 6.66 6.66 6.66 ChEMBL
D1 DRD1 Human Dopamine A pKi 5.71 5.71 5.71 ChEMBL
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 6.16 6.16 6.16 ChEMBL
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 6.46 6.46 6.46 ChEMBL
M1 ACM1 Human Acetylcholine (muscarinic) A pKi 6.15 6.15 6.15 ChEMBL
D3 DRD3 Human Dopamine A pKi 7.48 7.48 7.48 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 6.94 6.94 6.94 ChEMBL
A3 AA3R Human Adenosine A pKi 5.53 5.53 5.53 ChEMBL
μ OPRM Human Opioid A pKi 5.67 5.67 5.67 ChEMBL
CB1 CNR1 Human Cannabinoid A pKi 5.62 5.62 5.62 ChEMBL
D2 DRD2 Human Dopamine A pKi 6.93 6.93 6.93 ChEMBL
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 8.25 8.25 8.25 Drug Central
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 8.16 8.16 8.16 Drug Central
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 8.21 8.21 8.21 Drug Central
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 8.19 8.19 8.19 Drug Central
M1 ACM1 Human Acetylcholine (muscarinic) A pKi 8.21 8.21 8.21 Drug Central
M3 ACM3 Human Acetylcholine (muscarinic) A pKi 8.19 8.19 8.19 Drug Central
M4 ACM4 Human Acetylcholine (muscarinic) A pKi 8.21 8.21 8.21 Drug Central
α1D ADA1D Human Adrenoceptors A pKi 8.2 8.2 8.2 Drug Central
α2A ADA2A Human Adrenoceptors A pKi 8.18 8.18 8.18 Drug Central
α2B ADA2B Human Adrenoceptors A pKi 8.22 8.22 8.22 Drug Central
α2C ADA2C Human Adrenoceptors A pKi 8.13 8.13 8.13 Drug Central
D1 DRD1 Human Dopamine A pKi 8.24 8.24 8.24 Drug Central
D2 DRD2 Human Dopamine A pKi 8.16 8.16 8.16 Drug Central
D3 DRD3 Human Dopamine A pKi 8.13 8.13 8.13 Drug Central
H1 HRH1 Human Histamine A pKi 8.11 8.11 8.11 Drug Central
CB1 CNR1 Human Cannabinoid A pKi 8.25 8.25 8.25 Drug Central
α1B ADA1B Rat Adrenoceptors A pKi 8.21 8.21 8.21 Drug Central
M5 ACM5 Human Acetylcholine (muscarinic) A pKi 8.21 8.21 8.21 Drug Central
A3 AA3R Human Adenosine A pKi 8.26 8.26 8.26 Drug Central
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
α1B ADA1B Rat Adrenoceptors A pIC50 5.96 5.96 5.96 ChEMBL
α1A ADA1A Rat Adrenoceptors A pIC50 5.96 5.96 5.96 ChEMBL
α1D ADA1D Human Adrenoceptors A pIC50 5.96 5.96 5.96 ChEMBL
α2B ADA2B Human Adrenoceptors A pIC50 5.72 5.72 5.72 ChEMBL
M5 ACM5 Human Acetylcholine (muscarinic) A pIC50 5.96 5.96 5.96 ChEMBL
α2C ADA2C Human Adrenoceptors A pIC50 6.65 6.65 6.65 ChEMBL
M4 ACM4 Human Acetylcholine (muscarinic) A pIC50 5.25 5.25 5.25 ChEMBL
H1 HRH1 Human Histamine A pIC50 6.8 6.8 6.8 ChEMBL
M3 ACM3 Human Acetylcholine (muscarinic) A pIC50 5.83 5.83 5.83 ChEMBL
D2 DRD2 Rat Dopamine A pIC50 6.64 6.64 6.64 ChEMBL
5-HT1A 5HT1A Rat 5-Hydroxytryptamine A pIC50 5.37 5.37 5.37 ChEMBL
α2A ADA2A Human Adrenoceptors A pIC50 6.24 6.24 6.24 ChEMBL
D1 DRD1 Human Dopamine A pIC50 5.41 5.41 5.41 ChEMBL
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pIC50 5.96 5.96 5.96 ChEMBL
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pIC50 6.17 6.17 6.17 ChEMBL
M1 ACM1 Human Acetylcholine (muscarinic) A pIC50 5.53 5.53 5.53 ChEMBL
D3 DRD3 Human Dopamine A pIC50 7.01 7.01 7.01 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pIC50 6.39 6.39 6.39 ChEMBL
A3 AA3R Human Adenosine A pIC50 5.28 5.28 5.28 ChEMBL
μ OPRM Human Opioid A pIC50 5.28 5.45 5.62 ChEMBL
CB1 CNR1 Human Cannabinoid A pIC50 5.52 5.52 5.52 ChEMBL
D2 DRD2 Human Dopamine A pIC50 6.45 6.45 6.45 ChEMBL
δ OPRD Human Opioid A pIC50 8.26 8.26 8.26 Drug Central
κ OPRK Human Opioid A pIC50 8.3 8.3 8.3 Drug Central
μ OPRM Human Opioid A pIC50 8.25 8.25 8.25 Drug Central
5-HT1A 5HT1A Rat 5-Hydroxytryptamine A pIC50 8.27 8.27 8.27 Drug Central
α1A ADA1A Rat Adrenoceptors A pIC50 8.22 8.22 8.22 Drug Central
D2 DRD2 Rat Dopamine A pIC50 8.18 8.18 8.18 Drug Central
NPS NPSR1 Human Neuropeptide S A Potency 5.3 5.4 5.5 ChEMBL
δ OPRD Human Opioid A pIC50 5.44 5.44 5.44 ChEMBL
κ OPRK Human Opioid A pIC50 5.02 5.02 5.02 ChEMBL