fluspirilene


SMILES Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1
InChIKey QOYHHIBFXOOADH-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 7
Molecular weight (Da) 475.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug Yes

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 7.2 7.2 7.2 Guide to Pharmacology
5-HT1D 5HT1D Human 5-Hydroxytryptamine A pKi 6.0 6.0 6.0 Guide to Pharmacology
5-HT1E 5HT1E Human 5-Hydroxytryptamine A pKi 5.6 5.6 5.6 Guide to Pharmacology
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 8.0 8.0 8.0 Guide to Pharmacology
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 6.82 6.82 6.82 ChEMBL
5-HT2A 5HT2A Rat 5-Hydroxytryptamine A pKi 8.23 8.4 8.51 PDSP Ki database
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 7.25 7.25 7.25 PDSP Ki database
5-HT1B 5HT1B Human 5-Hydroxytryptamine A pKi 5.95 5.95 5.95 PDSP Ki database
5-HT1D 5HT1D Human 5-Hydroxytryptamine A pKi 5.3 5.3 5.3 PDSP Ki database
D1 DRD1 Rat Dopamine A pKi 6.35 6.35 6.35 PDSP Ki database
5-HT1E 5HT1E Human 5-Hydroxytryptamine A pKi 5.65 5.65 5.65 PDSP Ki database
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 8.02 8.02 8.02 PDSP Ki database
α2A ADA2A Human Adrenoceptors A pKi 6.24 6.24 6.24 PDSP Ki database
D2 DRD2 Human Dopamine A pKi 8.92 9.37 9.7 PDSP Ki database
α2B ADA2B Human Adrenoceptors A pKi 7.32 7.32 7.32 PDSP Ki database
H1 HRH1 Human Histamine A pKi 7.92 7.92 7.92 PDSP Ki database
D2 DRD2 Bovine Dopamine A pKi 9.22 9.22 9.22 PDSP Ki database
D1 DRD1 Bovine Dopamine A pKi 5.85 5.85 5.85 PDSP Ki database
TP TA2R Human Prostanoid A pKi 6.0 6.0 6.0 PDSP Ki database
δ OPRD Mouse Opioid A pKi 6.0 6.0 6.0 PDSP Ki database
μ OPRM Rat Opioid A pKi 7.11 7.11 7.11 PDSP Ki database
PAF PTAFR Human Platelet-activating factor A pKi 6.0 6.0 6.0 PDSP Ki database
D3 DRD3 Human Dopamine A pKi 8.37 8.73 9.4 PDSP Ki database
D4 DRD4 Human Dopamine A pKi 8.06 8.06 8.06 PDSP Ki database
NOP OPRX Human Opioid A pKi 6.3 6.3 6.3 PDSP Ki database
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 8.14 8.14 8.14 Drug Central
5-HT1B 5HT1B Human 5-Hydroxytryptamine A pKi 8.23 8.23 8.23 Drug Central
5-HT1D 5HT1D Human 5-Hydroxytryptamine A pKi 8.22 8.22 8.22 Drug Central
5-HT1E 5HT1E Human 5-Hydroxytryptamine A pKi 8.25 8.25 8.25 Drug Central
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 8.1 8.1 8.1 Drug Central
5-HT6 5HT6R Human 5-Hydroxytryptamine A pKi 8.23 8.23 8.23 Drug Central
α2A ADA2A Human Adrenoceptors A pKi 8.2 8.2 8.2 Drug Central
α2B ADA2B Human Adrenoceptors A pKi 8.14 8.14 8.14 Drug Central
D2 DRD2 Human Dopamine A pKi 8.03 8.03 8.03 Drug Central
D3 DRD3 Human Dopamine A pKi 8.08 8.08 8.08 Drug Central
D4 DRD4 Human Dopamine A pKi 8.09 8.09 8.09 Drug Central
H1 HRH1 Human Histamine A pKi 8.1 8.1 8.1 Drug Central
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 8.17 8.17 8.17 Drug Central
5-HT6 5HT6R Human 5-Hydroxytryptamine A pKi 5.92 5.92 5.92 ChEMBL
α2C ADA2C Human Adrenoceptors A pKi 8.14 8.14 8.14 Drug Central
α2C ADA2C Human Adrenoceptors A pKi 7.21 7.21 7.21 PDSP Ki database
β1 ADRB1 Human Adrenoceptors A pKi 8.21 8.21 8.21 Drug Central
β1 ADRB1 Human Adrenoceptors A pKi 6.23 6.23 6.23 PDSP Ki database
β2 ADRB2 Human Adrenoceptors A pKi 8.2 8.2 8.2 Drug Central
β2 ADRB2 Human Adrenoceptors A pKi 6.29 6.29 6.29 PDSP Ki database
H1 HRH1 Human Histamine A pKi 7.9 7.9 7.9 Guide to Pharmacology
NOP OPRX Human Opioid A pKi 8.2 8.2 8.2 Drug Central
NOP OPRX Human Opioid A pKi 6.3 6.3 6.3 ChEMBL
D3 DRD3 Rat Dopamine A pKi 8.96 8.96 8.96 PDSP Ki database
CCK2 GASR Rat Cholecystokinin A pKi 6.0 6.0 6.0 PDSP Ki database
5-HT1A 5HT1A Rat 5-Hydroxytryptamine A pKi 6.96 6.96 6.96 PDSP Ki database
H1 HRH1 Guinea pig Histamine A pKi 6.27 6.27 6.27 PDSP Ki database
5-HT1B 5HT1B Rat 5-Hydroxytryptamine A pKi 5.3 5.3 5.3 PDSP Ki database
κ OPRK Guinea pig Opioid A pKi 6.0 6.0 6.0 PDSP Ki database
D2 DRD2 Rat Dopamine A pKi 8.82 8.82 8.82 PDSP Ki database
5-HT2C K7GSR7 Pig 5-Hydroxytryptamine A pKi 5.74 5.74 5.74 PDSP Ki database
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
M1 ACM1 Rat Acetylcholine (muscarinic) A Potency 4.8 4.88 4.95 ChEMBL
NPS NPSR1 Human Neuropeptide S A Potency 4.9 5.0 5.1 ChEMBL