CHEMBL4278465


SMILES OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCCN(c2ccc(F)cc2)c2ccc(F)cc2)CC1
InChIKey CVRMQFHSOSVJET-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 8
Molecular weight (Da) 538.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT5A 5HT5A Human 5-Hydroxytryptamine A pKi 5.38 5.38 5.38 ChEMBL
D4 DRD4 Human Dopamine A pKi 5.0 5.0 5.0 ChEMBL
5-HT6 5HT6R Human 5-Hydroxytryptamine A pKi 5.78 5.78 5.78 ChEMBL
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 6.29 6.29 6.29 ChEMBL
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 5.95 5.95 5.95 ChEMBL
D3 DRD3 Human Dopamine A pKi 6.11 6.11 6.11 ChEMBL
δ OPRD Human Opioid A pKi 5.0 5.0 5.0 ChEMBL
κ OPRK Human Opioid A pKi 5.0 5.0 5.0 ChEMBL
μ OPRM Human Opioid A pKi 5.0 5.0 5.0 ChEMBL
D2 DRD2 Human Dopamine A pKi 6.26 6.26 6.26 ChEMBL
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 5.96 5.96 5.96 ChEMBL
5-HT1D 5HT1D Human 5-Hydroxytryptamine A pKi 5.97 5.97 5.97 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 5.22 5.22 5.22 ChEMBL
5-HT7 5HT7R Human 5-Hydroxytryptamine A pKi 6.09 6.09 6.09 ChEMBL
D1 DRD1 Human Dopamine A pKi 5.0 5.0 5.0 ChEMBL
D5 DRD5 Human Dopamine A pKi 6.13 6.13 6.13 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database