CHEMBL4287623


SMILES OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCC=C(c2ccc(F)cc2)c2ccc(F)cc2)CC1
InChIKey GOFKTWKLJPDQCU-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 7
Molecular weight (Da) 535.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
H2 HRH2 Human Histamine A pKi 6.28 6.28 6.28 ChEMBL
5-HT7 5HT7R Human 5-Hydroxytryptamine A pKi 5.0 5.0 5.0 ChEMBL
H1 HRH1 Human Histamine A pKi 6.14 6.14 6.14 ChEMBL
D4 DRD4 Human Dopamine A pKi 5.78 5.78 5.78 ChEMBL
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 5.66 5.66 5.66 ChEMBL
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 5.79 5.79 5.79 ChEMBL
D3 DRD3 Human Dopamine A pKi 6.26 6.26 6.26 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 5.96 5.96 5.96 ChEMBL
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 5.87 5.87 5.87 ChEMBL
κ OPRK Human Opioid A pKi 5.99 5.99 5.99 ChEMBL
μ OPRM Human Opioid A pKi 6.48 6.48 6.48 ChEMBL
D2 DRD2 Human Dopamine A pKi 6.5 6.5 6.5 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database