PENFLURIDOL


SMILES OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1
InChIKey MDLAAYDRRZXJIF-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 7
Molecular weight (Da) 523.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT5A 5HT5A Human 5-Hydroxytryptamine A pKi 6.0 6.0 6.0 ChEMBL
D5 DRD5 Human Dopamine A pKi 6.9 6.9 6.9 ChEMBL
5-HT1D 5HT1D Human 5-Hydroxytryptamine A pKi 5.45 5.45 5.45 ChEMBL
α1D ADA1D Human Adrenoceptors A pKi 6.22 6.22 6.22 ChEMBL
α2B ADA2B Human Adrenoceptors A pKi 6.4 6.4 6.4 ChEMBL
α2C ADA2C Human Adrenoceptors A pKi 6.35 6.35 6.35 ChEMBL
H2 HRH2 Human Histamine A pKi 6.0 6.0 6.0 ChEMBL
5-HT7 5HT7R Human 5-Hydroxytryptamine A pKi 6.55 6.55 6.55 ChEMBL
β3 ADRB3 Human Adrenoceptors A pKi 6.29 6.29 6.29 ChEMBL
H1 HRH1 Human Histamine A pKi 6.0 6.0 6.0 ChEMBL
D4 DRD4 Human Dopamine A pKi 6.0 6.0 6.0 ChEMBL
D1 DRD1 Human Dopamine A pKi 6.83 6.83 6.83 ChEMBL
5-HT6 5HT6R Human 5-Hydroxytryptamine A pKi 6.0 6.0 6.0 ChEMBL
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 6.74 6.74 6.74 ChEMBL
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 6.05 6.05 6.05 ChEMBL
D3 DRD3 Human Dopamine A pKi 6.87 6.87 6.87 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 6.44 6.44 6.44 ChEMBL
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 6.45 6.45 6.45 ChEMBL
δ OPRD Human Opioid A pKi 5.77 5.77 5.77 ChEMBL
κ OPRK Human Opioid A pKi 6.0 6.0 6.0 ChEMBL
μ OPRM Human Opioid A pKi 6.06 6.06 6.06 ChEMBL
D2 DRD2 Human Dopamine A pKi 6.8 6.8 6.8 ChEMBL
5-HT6 5HT6R Rat 5-Hydroxytryptamine A pKi 5.3 5.3 5.3 PDSP Ki database
5-HT7 5HT7R Rat 5-Hydroxytryptamine A pKi 5.3 5.3 5.3 PDSP Ki database
5-HT2A 5HT2A Rat 5-Hydroxytryptamine A pKi 6.82 7.03 7.23 PDSP Ki database
D4 DRD4 Rat Dopamine A pKi 7.51 7.51 7.51 PDSP Ki database
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 5.68 5.68 5.68 PDSP Ki database
D1 DRD1 Bovine Dopamine A pKi 5.8 5.8 5.8 PDSP Ki database
D2 DRD2 Bovine Dopamine A pKi 8.25 8.25 8.25 PDSP Ki database
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 8.19 8.19 8.19 Drug Central
5-HT1D 5HT1D Human 5-Hydroxytryptamine A pKi 8.26 8.26 8.26 Drug Central
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 8.19 8.19 8.19 Drug Central
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 8.17 8.17 8.17 Drug Central
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 8.25 8.25 8.25 Drug Central
5-HT5A 5HT5A Human 5-Hydroxytryptamine A pKi 8.22 8.22 8.22 Drug Central
5-HT6 5HT6R Human 5-Hydroxytryptamine A pKi 8.22 8.22 8.22 Drug Central
α1D ADA1D Human Adrenoceptors A pKi 8.21 8.21 8.21 Drug Central
α2B ADA2B Human Adrenoceptors A pKi 8.19 8.19 8.19 Drug Central
α2C ADA2C Human Adrenoceptors A pKi 8.2 8.2 8.2 Drug Central
β3 ADRB3 Human Adrenoceptors A pKi 8.2 8.2 8.2 Drug Central
D1 DRD1 Human Dopamine A pKi 8.17 8.17 8.17 Drug Central
D2 DRD2 Human Dopamine A pKi 8.17 8.17 8.17 Drug Central
D3 DRD3 Human Dopamine A pKi 8.16 8.16 8.16 Drug Central
D4 DRD4 Human Dopamine A pKi 8.22 8.22 8.22 Drug Central
D5 DRD5 Human Dopamine A pKi 8.16 8.16 8.16 Drug Central
H1 HRH1 Human Histamine A pKi 8.22 8.22 8.22 Drug Central
H2 HRH2 Human Histamine A pKi 8.22 8.22 8.22 Drug Central
δ OPRD Human Opioid A pKi 8.24 8.24 8.24 Drug Central
κ OPRK Human Opioid A pKi 8.22 8.22 8.22 Drug Central
μ OPRM Human Opioid A pKi 8.22 8.22 8.22 Drug Central
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database