CHEMBL4473709


SMILES C=CCN1C(=O)C2(Nc3ccccc3C(=O)N2c2ccccc2OC)c2ccccc21
InChIKey ICNRHSXEHSIYCI-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 4
Molecular weight (Da) 411.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
OX1 OX1R Human Orexin A pKi 4.67 4.79 4.92 ChEMBL
OX2 OX2R Human Orexin A pKi 5.92 5.96 6.0 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
OX1 OX1R Human Orexin A pIC50 4.68 4.68 4.68 ChEMBL
OX2 OX2R Human Orexin A pIC50 6.16 6.16 6.16 ChEMBL