CHEMBL476108


SMILES O=C(CCCN1CCCN(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1
InChIKey MVKKLGNVARQKRP-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 3
Hydrogen bond donors 0
Rotatable bonds 6
Molecular weight (Da) 374.2

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
H1 HRH1 Human Histamine A pKi 6.72 6.72 6.72 ChEMBL
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 6.3 6.3 6.3 ChEMBL
D1 DRD1 Human Dopamine A pKi 6.79 6.79 6.79 ChEMBL
D4 DRD4 Human Dopamine A pKi 8.18 8.18 8.18 ChEMBL
M1 ACM1 Human Acetylcholine (muscarinic) A pKi 6.06 6.06 6.06 ChEMBL
5-HT6 5HT6R Human 5-Hydroxytryptamine A pKi 6.53 6.53 6.53 ChEMBL
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 5.85 5.85 5.85 ChEMBL
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 6.93 6.93 6.93 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 7.63 7.63 7.63 ChEMBL
D3 DRD3 Human Dopamine A pKi 6.8 6.8 6.8 ChEMBL
D2 DRD2 Human Dopamine A pKi 7.36 7.36 7.36 ChEMBL
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 6.31 6.31 6.31 PDSP Ki database
5-HT6 5HT6R Human 5-Hydroxytryptamine A pKi 6.53 6.53 6.53 PDSP Ki database
M1 ACM1 Human Acetylcholine (muscarinic) A pKi 6.06 6.06 6.06 PDSP Ki database
D1 DRD1 Human Dopamine A pKi 6.79 6.79 6.79 PDSP Ki database
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 6.93 6.93 6.93 PDSP Ki database
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 5.85 5.85 5.85 PDSP Ki database
D2 DRD2 Human Dopamine A pKi 7.36 7.36 7.36 PDSP Ki database
D3 DRD3 Human Dopamine A pKi 6.8 6.8 6.8 PDSP Ki database
D4 DRD4 Human Dopamine A pKi 8.18 8.18 8.18 PDSP Ki database
H1 HRH1 Human Histamine A pKi 6.72 6.72 6.72 PDSP Ki database
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 7.63 7.63 7.63 PDSP Ki database
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database