CHEMBL454890


SMILES CN1CCN(c2nc(NCc3ccoc3)c3cc(Cl)ccc3n2)CC1
InChIKey VCADIWSEVTZZOR-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 6
Hydrogen bond donors 1
Rotatable bonds 4
Molecular weight (Da) 357.1

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
H4 HRH4 Rat Histamine A pKi 7.61 7.61 7.61 ChEMBL
H4 HRH4 Human Histamine A pKi 7.05 7.31 7.57 ChEMBL
H1 HRH1 Human Histamine A pKi 7.01 7.01 7.01 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
H4 HRH4 Human Histamine A pIC50 6.84 6.84 6.84 ChEMBL