CHEMBL4597218


SMILES CC(C)(C)CNc1nccc(N2CCc3nc[nH]c3C2)n1
InChIKey GYJOUMCDNZCUAE-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 3
Molecular weight (Da) 286.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
H4 HRH4 Mouse Histamine A pKi 8.91 8.91 8.91 ChEMBL
H4 HRH4 Human Histamine A pKi 8.29 8.51 8.93 ChEMBL
H3 HRH3 Human Histamine A pKi 8.48 8.75 9.27 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
H4 HRH4 Mouse Histamine A pEC50 7.9 8.48 9.6 ChEMBL
H4 HRH4 Rat Histamine A pEC50 7.78 9.04 10.3 ChEMBL
H4 HRH4 Human Histamine A pEC50 8.38 9.14 9.91 ChEMBL