CHEMBL4764679


SMILES CN1CCc2ccc(OCCCN3CCC(c4noc5cc(F)ccc45)CC3)cc2C1=O
InChIKey RDGPIFCCGRDXMY-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 5
Hydrogen bond donors 0
Rotatable bonds 6
Molecular weight (Da) 437.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT7 5HT7R Rat 5-Hydroxytryptamine A pKi 8.31 8.31 8.31 ChEMBL
5-HT2C 5HT2C Rat 5-Hydroxytryptamine A pKi 5.77 5.77 5.77 ChEMBL
H1 HRH1 Guinea pig Histamine A pKi 5.92 5.92 5.92 ChEMBL
D2 DRD2 Rat Dopamine A pKi 8.16 8.16 8.16 ChEMBL
5-HT1A 5HT1A Rat 5-Hydroxytryptamine A pKi 8.04 8.04 8.04 ChEMBL
5-HT6 5HT6R Human 5-Hydroxytryptamine A pKi 8.02 8.02 8.02 ChEMBL
D3 DRD3 Human Dopamine A pKi 6.65 6.65 6.65 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT6 5HT6R Human 5-Hydroxytryptamine A pIC50 7.4 7.4 7.4 ChEMBL
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pIC50 7.25 7.25 7.25 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pIC50 7.33 7.33 7.33 ChEMBL
5-HT7 5HT7R Human 5-Hydroxytryptamine A pIC50 7.9 7.9 7.9 ChEMBL
D2 DRD2 Human Dopamine A pIC50 8.2 8.2 8.2 ChEMBL