Biased Signaling Atlas

haloperidol

Agent/drug
Bioactivity

haloperidol

SMILES	O=C(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1
InChIKey	LNEPOXFFQSENCJ-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	3
Hydrogen bond donors	1
Rotatable bonds	6
Molecular weight (Da)	375.1

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central PubChem GPCRdb
Structure pdb	6LUQ
Ligand site mutations	5-HT_2A 5-HT_2C D₁ D₂ D₃ D₅

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1A	ADA1A	Rat	Adrenoceptors	A	pKd	7.76	7.76	7.76	ChEMBL
α_1A	ADA1A	Rat	Adrenoceptors	A	pKi	7.55	7.55	7.55	ChEMBL
α_1A	ADA1A	Human	Adrenoceptors	A	pKi	7.96	7.96	7.96	ChEMBL
α_1A	ADA1A	Human	Adrenoceptors	A	pKi	8.10	8.10	8.10	Drug Central
α_1A	ADA1A	Rat	Adrenoceptors	A	pKd	8.11	8.11	8.11	Drug Central
α_1B	ADA1B	Rat	Adrenoceptors	A	pKi	8.31	8.31	8.31	ChEMBL
α_1B	ADA1B	Rat	Adrenoceptors	A	pKi	8.14	8.14	8.14	PDSP Ki database
α_1B	ADA1B	Human	Adrenoceptors	A	pKi	8.10	8.10	8.10	PDSP Ki database
α_1B	ADA1B	Human	Adrenoceptors	A	pKi	8.09	8.09	8.09	Drug Central
α_1B	ADA1B	Rat	Adrenoceptors	A	pKi	8.08	8.08	8.08	Drug Central
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	7.39	7.39	7.39	ChEMBL
α_1D	ADA1D	Rat	Adrenoceptors	A	pKi	7.54	7.54	7.54	PDSP Ki database
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	7.92	7.92	7.92	PDSP Ki database
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	8.12	8.12	8.12	Drug Central
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	5.73	5.73	5.73	ChEMBL
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	5.95	6.04	6.33	PDSP Ki database
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	8.23	8.23	8.23	Drug Central
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	6.21	6.21	6.21	ChEMBL
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	6.32	6.32	6.32	PDSP Ki database
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	8.20	8.20	8.20	Drug Central

Showing 1 to 20 of 182 entries

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Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1A	ADA1A	Bovine	Adrenoceptors	A	pIC50	7.70	7.70	7.70	ChEMBL
α_1A	ADA1A	Rat	Adrenoceptors	A	pIC50	7.17	7.17	7.17	ChEMBL
α_1A	ADA1A	Bovine	Adrenoceptors	A	pIC50	8.11	8.11	8.11	Drug Central
α_1B	ADA1B	Rat	Adrenoceptors	A	pIC50	8.05	8.05	8.05	ChEMBL
α_1D	ADA1D	Human	Adrenoceptors	A	pIC50	7.08	7.08	7.08	ChEMBL
α_2A	ADA2A	Human	Adrenoceptors	A	pIC50	5.30	5.30	5.30	ChEMBL
α_2B	ADA2B	Human	Adrenoceptors	A	pIC50	5.87	5.87	5.87	ChEMBL
α_2C	ADA2C	Human	Adrenoceptors	A	pIC50	5.73	5.73	5.73	ChEMBL
μ	OPRM	Human	Opioid	A	pIC50	5.61	5.61	5.61	ChEMBL
5-HT_1A	5HT1A	Rat	5-Hydroxytryptamine	A	pIC50	5.15	5.27	5.70	ChEMBL
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pIC50	5.82	5.82	5.82	ChEMBL
5-HT_2A	5HT2A	Bovine	5-Hydroxytryptamine	A	pIC50	7.52	7.52	7.52	ChEMBL
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pIC50	6.54	6.83	7.12	ChEMBL
5-HT_2A	5HT2A	Bovine	5-Hydroxytryptamine	A	pIC50	8.12	8.12	8.12	Drug Central
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pIC50	5.69	5.69	5.69	ChEMBL
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pIC50	5.47	5.47	5.47	ChEMBL
D₁	DRD1	Rat	Dopamine	A	pIC50	5.82	6.69	7.44	ChEMBL
D₁	DRD1	Human	Dopamine	A	pIC50	6.96	6.96	6.96	ChEMBL
D₂	DRD2	Bovine	Dopamine	A	pIC50	7.52	8.22	8.92	ChEMBL
D₂	DRD2	Rat	Dopamine	A	pIC50	7.39	8.08	10.12	ChEMBL

Showing 1 to 20 of 31 entries

haloperidol

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Distribution across phases (no. indications)

Phase I 0

Phase II 5

Phase III 16

Phase IV 35

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central PubChem GPCRdb
Structure pdb	6LUQ
Ligand site mutations	5-HT_2A 5-HT_2C D₁ D₂ D₃ D₅

Sankey plot

Drug Information

Search:

Target					Disease

Gene	Protein	Receptor family	Ligand type	Class	Name	Phase	ICD11	ATC	Association score

5HT1A	5-HT_1A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Aggressive behaviour	4	MB23.0	N05A	0.370
5HT1A	5-HT_1A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Bipolar type I disorder, unspecified	3	6A60.Z	N05A	0.591
5HT1A	5-HT_1A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Conduct-dissocial disorder, unspecified	4	6C91.Z	N05A	0.370
5HT1A	5-HT_1A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Mood disorders, unspecified	2	6A8Z	N05A	0.024
5HT1A	5-HT_1A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Nausea	3	MD90.0	N05A	0.001
5HT1A	5-HT_1A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Restlessness	3	MB24.F	N05A	0.575
5HT1A	5-HT_1A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Schizoaffective disorder, unspecified	4	6A21.Z	N05A	0.590
5HT1A	5-HT_1A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Schizophrenia or other primary psychotic disorders, unspecified	4	6A2Z	N05A	0.566
5HT1A	5-HT_1A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Schizophrenia, episode unspecified	4	6A20.Z	N05A	0.622
5HT1A	5-HT_1A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Tourette syndrome	4	8A05.00	N05A	0.554
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Aggressive behaviour	4	MB23.0	N05A	0.599
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Bipolar type I disorder, unspecified	3	6A60.Z	N05A	0.609
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Conduct-dissocial disorder, unspecified	4	6C91.Z	N05A	0.530
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Delirium, unspecified or unknown cause	4	6D70.Z	N05A	0.588
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Mood disorders, unspecified	2	6A8Z	N05A	0.490
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Nausea	3	MD90.0	N05A	0.337
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Restlessness	3	MB24.F	N05A	0.602
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Schizoaffective disorder, unspecified	4	6A21.Z	N05A	0.606
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Schizophrenia or other primary psychotic disorders, unspecified	4	6A2Z	N05A	0.609
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Schizophrenia, episode unspecified	4	6A20.Z	N05A	0.620

Showing 1 to 20 of 54 entries

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Main reference

haloperidol

haloperidol

Chemical Properties

Database connections

Bioactivities

haloperidol

Drug properties

Distribution across phases (no. indications)

Database connections

Sankey plot

Drug Information