CHEMBL5204071


SMILES COc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)c(O)c1
InChIKey BLLYZWFUXWXJGP-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 3
Hydrogen bond donors 3
Rotatable bonds 2
Molecular weight (Da) 312.1

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT1E 5HT1E Human 5-Hydroxytryptamine A pKi 5.85 5.85 5.85 ChEMBL
5-HT5A 5HT5A Human 5-Hydroxytryptamine A pKi 6.64 6.64 6.64 ChEMBL
5-HT1B 5HT1B Human 5-Hydroxytryptamine A pKi 7.15 7.15 7.15 ChEMBL
5-HT1D 5HT1D Human 5-Hydroxytryptamine A pKi 6.96 6.96 6.96 ChEMBL
5-HT7 5HT7R Human 5-Hydroxytryptamine A pKi 7.59 7.59 7.59 ChEMBL
D4 DRD4 Human Dopamine A pKi 6.44 6.44 6.44 ChEMBL
5-HT6 5HT6R Human 5-Hydroxytryptamine A pKi 7.16 7.16 7.16 ChEMBL
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 8.36 8.36 8.36 ChEMBL
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 7.3 7.3 7.3 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 6.6 6.6 6.6 ChEMBL
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 7.03 7.03 7.03 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pEC50 8.88 8.89 8.89 ChEMBL
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pEC50 8.99 8.99 8.99 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pEC50 8.49 8.5 8.5 ChEMBL