TETRAHYDROPALMATINE


SMILES COc1cc2c(cc1OC)[C@@H]1Cc3ccc(OC)c(OC)c3CN1CC2
InChIKey AEQDJSLRWYMAQI-KRWDZBQOSA-N

Chemical properties

Hydrogen bond acceptors 5
Hydrogen bond donors 0
Rotatable bonds 4
Molecular weight (Da) 355.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
D5 DRD5 Human Dopamine A pKi 6.52 6.52 6.52 ChEMBL
D1 DRD1 Human Dopamine A pKi 6.64 6.73 6.82 ChEMBL
D3 DRD3 Human Dopamine A pKi 5.86 5.86 5.86 ChEMBL
D2 DRD2 Human Dopamine A pKi 5.95 5.95 5.95 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
D1 DRD1 Human Dopamine A pIC50 5.79 5.79 5.79 ChEMBL
D2 DRD2 Human Dopamine A pIC50 6.35 6.35 6.35 ChEMBL