CHEMBL492231


SMILES Nc1nc2c(c(N3CCNCC3)n1)CCCCC2c1ccccc1
InChIKey LTSQOGQDXSXTPV-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 2
Molecular weight (Da) 323.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
H4 HRH4 Rat Histamine A pKi 8.35 8.35 8.35 ChEMBL
H3 HRH3 Rat Histamine A pKi 6.18 6.18 6.18 ChEMBL
H4 HRH4 Human Histamine A pKi 7.4 7.4 7.4 ChEMBL
H3 HRH3 Human Histamine A pKi 5.65 5.65 5.65 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
H4 HRH4 Mouse Histamine A pEC50 7.34 7.34 7.34 ChEMBL
H4 HRH4 Rat Histamine A pEC50 7.26 7.26 7.26 ChEMBL