CHEMBL565894


SMILES CN(Cc1ccc(F)c(C(F)(F)F)c1)C(=O)C(C)(CCN1CCC(N2CCCC2=O)CC1)c1ccc(Cl)c(Cl)c1
InChIKey XNEWLEJBYAVWCK-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 3
Hydrogen bond donors 0
Rotatable bonds 8
Molecular weight (Da) 601.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
NK3 NK3R Guinea pig Tachykinin A pKd 7.96 7.96 7.96 ChEMBL
NK3 NK3R Guinea pig Tachykinin A pKi 8.74 8.77 8.8 ChEMBL
NK3 NK3R Human Tachykinin A pKi 9.1 9.1 9.1 ChEMBL
NK3 NK3R Human Tachykinin A pKd 8.05 8.05 8.05 ChEMBL
NK2 NK2R Human Tachykinin A pKi 6.96 6.96 6.96 ChEMBL
NK1 NK1R Human Tachykinin A pKi 6.74 6.74 6.74 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database