L-158809


SMILES CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1
InChIKey YFWXFHNZGKNDBC-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 6
Hydrogen bond donors 1
Rotatable bonds 5
Molecular weight (Da) 409.2

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
AT1 AGTRA Rat Angiotensin A pKi 9.35 9.35 9.35 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
AT1 AGTR1 Bovine Angiotensin A pIC50 7.57 7.57 7.57 ChEMBL
AT1 AGTRA Rat Angiotensin A pIC50 9.4 9.4 9.4 ChEMBL
AT1 AGTRB Rat Angiotensin A pIC50 9.4 9.4 9.4 ChEMBL
AT2 AGTR2 Rat Angiotensin A pIC50 4.3 5.87 7.43 ChEMBL
AT1 AGTR1 Rabbit Angiotensin A pIC50 9.1 9.41 9.52 ChEMBL
AT2 AGTR2 Human Angiotensin A pIC50 9.7 9.7 9.7 ChEMBL
AT1 AGTR1 Human Angiotensin A pIC50 8.57 9.04 9.52 ChEMBL