CLOROTEPINE


SMILES CN1CCN(C2Cc3ccccc3Sc3ccc(Cl)cc32)CC1
InChIKey XRYLGRGAWQSVQW-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 3
Hydrogen bond donors 0
Rotatable bonds 1
Molecular weight (Da) 344.1

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
α1B ADA1B Golden hamster Adrenoceptors A pKi 9.25 9.25 9.25 ChEMBL
α1A ADA1A Bovine Adrenoceptors A pKi 9.18 9.18 9.18 ChEMBL
D3 DRD3 Rat Dopamine A pKi 8.62 8.62 8.62 ChEMBL
α1D ADA1D Rat Adrenoceptors A pKi 9.11 9.11 9.11 ChEMBL
D1 DRD1 Rat Dopamine A pKi 8.64 8.64 8.64 ChEMBL
H1 HRH1 Human Histamine A pKi 9.72 9.72 9.72 ChEMBL
D2 DRD2 Rat Dopamine A pKi 9.3 9.3 9.3 ChEMBL
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 9.24 9.24 9.24 ChEMBL
D2 DRD2 Human Dopamine A pKi 9.17 9.17 9.17 ChEMBL
5-HT6 5HT6R Rat 5-Hydroxytryptamine A pKi 7.75 8.57 9.39 PDSP Ki database
5-HT7 5HT7R Rat 5-Hydroxytryptamine A pKi 8.89 9.16 9.42 PDSP Ki database
5-HT6 5HT6R Human 5-Hydroxytryptamine A pKi 8.59 8.66 8.74 PDSP Ki database
5-HT7 5HT7R Guinea pig 5-Hydroxytryptamine A pKi 7.49 8.04 8.6 PDSP Ki database
D2 DRD2 Rat Dopamine A pKi 7.9 8.67 9.3 PDSP Ki database
TA1 TAAR1 Human Trace amine A pKi 6.31 6.31 6.31 PDSP Ki database
5-HT2A 5HT2A Rat 5-Hydroxytryptamine A pKi 9.64 9.64 9.64 PDSP Ki database
D3 DRD3 Rat Dopamine A pKi 8.62 8.62 8.62 PDSP Ki database
D1 DRD1 Rat Dopamine A pKi 8.64 8.64 8.64 PDSP Ki database
D2 DRD2 Human Dopamine A pKi 9.15 9.43 9.7 PDSP Ki database
D3 DRD3 Human Dopamine A pKi 9.05 9.38 9.7 PDSP Ki database
D4 DRD4 Human Dopamine A pKi 9.4 9.4 9.4 PDSP Ki database
H1 HRH1 Human Histamine A pKi 5.0 5.0 5.0 PDSP Ki database
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 8.03 8.03 8.03 Drug Central
5-HT6 5HT6R Human 5-Hydroxytryptamine A pKi 8.06 8.06 8.06 Drug Central
D2 DRD2 Human Dopamine A pKi 8.04 8.04 8.04 Drug Central
D3 DRD3 Human Dopamine A pKi 8.03 8.03 8.03 Drug Central
D4 DRD4 Human Dopamine A pKi 8.03 8.03 8.03 Drug Central
H1 HRH1 Human Histamine A pKi 8.01 8.01 8.01 Drug Central
TA1 TAAR1 Human Trace amine A pKi 8.2 8.2 8.2 Drug Central
5-HT2A 5HT2A Rat 5-Hydroxytryptamine A pKi 8.02 8.02 8.02 Drug Central
D3 DRD3 Rat Dopamine A pKi 8.06 8.06 8.06 Drug Central
α1D ADA1D Rat Adrenoceptors A pKi 8.04 8.04 8.04 Drug Central
D1 DRD1 Rat Dopamine A pKi 8.06 8.06 8.06 Drug Central
D2 DRD2 Rat Dopamine A pKi 8.03 8.03 8.03 Drug Central
α1B ADA1B Golden hamster Adrenoceptors A pKi 8.03 8.03 8.03 Drug Central
α1A ADA1A Bovine Adrenoceptors A pKi 8.04 8.04 8.04 Drug Central
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
D1 DRD1 Rat Dopamine A pIC50 8.66 8.66 8.66 ChEMBL
D2 DRD2 Rat Dopamine A pIC50 8.62 8.62 8.62 ChEMBL