LATREPIRDINE


SMILES Cc1ccc2c(c1)c1c(n2CCc2ccc(C)nc2)CCN(C)C1
InChIKey JNODQFNWMXFMEV-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 3
Hydrogen bond donors 0
Rotatable bonds 3
Molecular weight (Da) 319.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT6 5HT6R Rat 5-Hydroxytryptamine A pKi 6.92 6.92 6.92 ChEMBL
5-HT7 5HT7R Human 5-Hydroxytryptamine A pKi 8.1 8.1 8.1 ChEMBL
α1A ADA1A Human Adrenoceptors A pKi 7.22 7.22 7.22 ChEMBL
α2A ADA2A Human Adrenoceptors A pKi 6.96 6.96 6.96 ChEMBL
5-HT6 5HT6R Human 5-Hydroxytryptamine A pKi 7.47 7.51 7.58 ChEMBL
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 7.12 7.12 7.12 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 7.21 7.21 7.21 ChEMBL
D2 DRD2 Human Dopamine A pKi 6.2 6.2 6.2 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
H1 HRH1 Human Histamine A pIC50 5.8 6.3 6.8 ChEMBL
5-HT6 5HT6R Human 5-Hydroxytryptamine A pIC50 5.94 6.01 6.05 ChEMBL