LY-294002


SMILES O=c1cc(N2CCOCC2)oc2c(-c3ccccc3)cccc12
InChIKey CZQHHVNHHHRRDU-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 4
Hydrogen bond donors 0
Rotatable bonds 2
Molecular weight (Da) 307.1

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 4.63 4.63 4.63 ChEMBL
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 6.28 6.28 6.28 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 6.1 6.1 6.1 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pIC50 4.43 4.43 4.43 ChEMBL
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pIC50 6.0 6.0 6.0 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pIC50 5.55 5.55 5.55 ChEMBL
TSH TSHR Human Glycoprotein hormone A Potency 4.4 4.8 5.2 ChEMBL