(R)-α-methylhistamine


SMILES C[C@H](Cc1cnc[nH]1)N
InChIKey XNQIOISZPFVUFG-RXMQYKEDSA-N

Chemical properties

Hydrogen bond acceptors 2
Hydrogen bond donors 2
Rotatable bonds 2
Molecular weight (Da) 125.1

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Ligand site mutations H3

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
H3 HRH3 Human Histamine A pKi 7.2 8.61 9.26 ChEMBL
H3 HRH3 Human Histamine A pKd 9.2 9.2 9.2 Guide to Pharmacology
H3 HRH3 Human Histamine A pKi 8.4 8.8 9.2 Guide to Pharmacology
H4 HRH4 Human Histamine A pKi 6.6 6.73 6.84 ChEMBL
H4 HRH4 Human Histamine A pKd 7.2 7.2 7.2 Guide to Pharmacology
H4 HRH4 Human Histamine A pKi 6.5 6.7 6.9 Guide to Pharmacology
H4 HRH4 Mouse Histamine A pKi 6.4 6.4 6.4 Guide to Pharmacology
H4 HRH4 Rat Histamine A pKi 6.2 6.2 6.2 Guide to Pharmacology
H3 HRH3 Rat Histamine A pKi 8.0 8.35 8.7 Guide to Pharmacology
H3 HRH3 Mouse Histamine A pKi 8.4 8.4 8.4 Guide to Pharmacology
H3 HRH3 Guinea pig Histamine A pKd 7.8 7.8 7.8 ChEMBL
H3 HRH3 Guinea pig Histamine A pKi 8.82 9.38 10.07 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
H3 HRH3 Rat Histamine A pIC50 8.82 8.82 8.82 ChEMBL
H3 HRH3 Human Histamine A pEC50 7.4 8.65 9.5 ChEMBL
H3 HRH3 Human Histamine A pIC50 8.64 8.64 8.64 ChEMBL
H4 HRH4 Human Histamine A pEC50 5.95 6.08 6.2 ChEMBL