OXYMORPHONE


SMILES CN1CC[C@]23c4c5ccc(O)c4O[C@H]2C(=O)CC[C@@]3(O)[C@H]1C5
InChIKey UQCNKQCJZOAFTQ-ISWURRPUSA-N

Chemical properties

Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 0
Molecular weight (Da) 301.1

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
κ OPRK Rat Opioid A pKi 6.36 6.69 7.02 ChEMBL
μ OPRM Mouse Opioid A pKi 8.3 8.3 8.3 ChEMBL
δ OPRD Mouse Opioid A pKi 6.14 6.16 6.21 ChEMBL
κ OPRK Guinea pig Opioid A pKi 6.14 6.86 7.24 ChEMBL
μ OPRM Rat Opioid A pKi 7.58 8.0 9.01 ChEMBL
δ OPRD Human Opioid A pKi 6.84 7.1 7.3 ChEMBL
κ OPRK Human Opioid A pKi 7.6 7.6 7.6 ChEMBL
μ OPRM Human Opioid A pKi 8.75 8.75 8.75 ChEMBL
μ OPRM Rat Opioid A pKi 7.52 8.51 9.01 PDSP Ki database
δ OPRD Rat Opioid A pKi 7.09 7.09 7.09 PDSP Ki database
κ OPRK Rat Opioid A pKi 7.21 7.21 7.21 PDSP Ki database
δ OPRD Human Opioid A pKi 8.14 8.14 8.14 Drug Central
κ OPRK Human Opioid A pKi 8.17 8.17 8.17 Drug Central
μ OPRM Human Opioid A pKi 8.02 8.02 8.02 Drug Central
δ OPRD Rat Opioid A pKi 8.15 8.15 8.15 Drug Central
δ OPRD Mouse Opioid A pKi 8.21 8.21 8.21 Drug Central
μ OPRM Rat Opioid A pKi 8.05 8.05 8.05 Drug Central
κ OPRK Guinea pig Opioid A pKi 8.14 8.14 8.14 Drug Central
μ OPRM Mouse Opioid A pKi 8.08 8.08 8.08 Drug Central
κ OPRK Rat Opioid A pKi 8.15 8.15 8.15 Drug Central
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
κ OPRK Guinea pig Opioid A pIC50 6.2 6.2 6.2 ChEMBL
δ OPRD Human Opioid A pIC50 7.35 7.35 7.35 ChEMBL
μ OPRM Human Opioid A pEC50 8.11 8.11 8.11 ChEMBL