Biased Signaling Atlas

TIAPRIDE

Agent/drug
Bioactivity

TIAPRIDE

SMILES	CCN(CC)CCNC(=O)c1cc(S(C)(=O)=O)ccc1OC
InChIKey	JTVPZMFULRWINT-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	5
Hydrogen bond donors	1
Rotatable bonds	8
Molecular weight (Da)	328.1

Database connections

ChEMBL_compound_ids PubChem DrugBank PubChem GPCRdb
Ligand site mutations	D₂ D₄

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Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_2A	ADA2A	Human	Adrenoceptors	A	pKi	6.11	6.11	6.11	ChEMBL
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	8.21	8.21	8.21	Drug Central
D₂	DRD2	Human	Dopamine	A	pKi	6.39	6.39	6.39	ChEMBL
D₂	DRD2	Rat	Dopamine	A	pKi	7.11	7.11	7.11	PDSP Ki database
D₂	DRD2	Human	Dopamine	A	pKi	6.65	7.08	7.51	PDSP Ki database
D₂	DRD2	Human	Dopamine	A	pKi	8.15	8.15	8.15	Drug Central
D₃	DRD3	Human	Dopamine	A	pKi	6.41	6.41	6.41	ChEMBL
D₃	DRD3	Human	Dopamine	A	pKi	6.49	6.75	7.02	PDSP Ki database
D₃	DRD3	Human	Dopamine	A	pKi	8.17	8.17	8.17	Drug Central
D₄	DRD4	Human	Dopamine	A	pKi	7.85	7.85	7.85	PDSP Ki database
D₄	DRD4	Human	Dopamine	A	pKi	8.10	8.10	8.10	Drug Central

Showing 1 to 11 of 11 entries

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Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_2A	ADA2A	Human	Adrenoceptors	A	pIC50	5.68	5.68	5.68	ChEMBL
D₂	DRD2	Human	Dopamine	A	pIC50	5.91	5.91	5.91	ChEMBL
D₃	DRD3	Human	Dopamine	A	pIC50	5.94	5.94	5.94	ChEMBL
M₁	ACM1	Rat	Acetylcholine (muscarinic)	A	Potency	5.00	5.72	6.45	ChEMBL
TSH	TSHR	Human	Glycoprotein hormone	A	Potency	5.20	5.20	5.20	ChEMBL

Showing 1 to 5 of 5 entries

TIAPRIDE

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Distribution across phases (no. indications)

Phase I 0

Phase II 0

Phase III 0

Phase IV 77

Database connections

ChEMBL_compound_ids PubChem DrugBank PubChem GPCRdb
Ligand site mutations	D₂ D₄

Sankey plot

Drug Information

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Target					Disease

Gene	Protein	Receptor family	Ligand type	Class	Name	Phase	ICD11	ATC	Association score

5HT1A	5-HT_1A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Alcohol dependence, unspecified	4	6C40.2Z		0.456
5HT1A	5-HT_1A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Huntington disease	4	8A01.10		0.015
5HT1A	5-HT_1A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Movement disorders, unspecified	4	8A0Z		0.474
5HT1A	5-HT_1A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Restlessness	4	MB24.F		0.575
5HT1B	5-HT_1B receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Alcohol dependence, unspecified	4	6C40.2Z		0.020
5HT1B	5-HT_1B receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Huntington disease	4	8A01.10		0.016
5HT1B	5-HT_1B receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Movement disorders, unspecified	4	8A0Z		0.370
5HT1D	5-HT_1D receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Alcohol dependence, unspecified	4	6C40.2Z		0.004
5HT1D	5-HT_1D receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Huntington disease	4	8A01.10		0.002
5HT1D	5-HT_1D receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Movement disorders, unspecified	4	8A0Z		0.370
5HT1E	5-HT_1E receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Movement disorders, unspecified	4	8A0Z		0.370
5HT1F	5-HT_1F receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Movement disorders, unspecified	4	8A0Z		0.370
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Alcohol dependence, unspecified	4	6C40.2Z		0.268
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Huntington disease	4	8A01.10		0.275
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Movement disorders, unspecified	4	8A0Z		0.530
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Restlessness	4	MB24.F		0.602
5HT2B	5-HT_2B receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Movement disorders, unspecified	4	8A0Z		0.370
5HT2C	5-HT_2C receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Alcohol dependence, unspecified	4	6C40.2Z		0.389
5HT2C	5-HT_2C receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Huntington disease	4	8A01.10		0.272
5HT2C	5-HT_2C receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Movement disorders, unspecified	4	8A0Z		0.528

Showing 1 to 20 of 46 entries

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Main reference

TIAPRIDE

TIAPRIDE

Chemical Properties

Database connections

Bioactivities

TIAPRIDE

Drug properties

Distribution across phases (no. indications)

Database connections

Sankey plot

Drug Information