Biased Signaling Atlas

isoprenaline

Agent/drug
Bioactivity

isoprenaline

SMILES	CC(C)NCC(O)c1ccc(O)c(O)c1
InChIKey	JWZZKOKVBUJMES-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	4
Hydrogen bond donors	4
Rotatable bonds	4
Molecular weight (Da)	211.1

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central PubChem GPCRdb
Ligand site mutations	β₁ β₂ β₃

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_2A	ADA2A	Pig	Adrenoceptors	A	pKi	5.00	5.00	5.00	PDSP Ki database
α_2A	ADA2A	Mouse	Adrenoceptors	A	pKi	5.00	5.00	5.00	PDSP Ki database
β₁	ADRB1	Human	Adrenoceptors	A	pKi	6.10	6.55	7.00	Guide to Pharmacology
β₁	ADRB1	Mouse	Adrenoceptors	A	pKi	6.66	6.66	6.66	ChEMBL
β₁	ADRB1	Rat	Adrenoceptors	A	pKi	6.17	6.79	7.10	ChEMBL
β₁	ADRB1	Human	Adrenoceptors	A	pKi	5.80	6.25	6.71	ChEMBL
β₁	H0W3H1	Guinea pig	Adrenoceptors	A	pKi	6.33	6.33	6.33	PDSP Ki database
β₁	ADRB1	Human	Adrenoceptors	A	pKi	6.65	6.65	6.65	PDSP Ki database
β₁	ADRB1	Mouse	Adrenoceptors	A	pKi	8.18	8.18	8.18	Drug Central
β₂	ADRB2	Human	Adrenoceptors	A	pKi	6.40	6.50	6.60	Guide to Pharmacology
β₂	ADRB2	Bovine	Adrenoceptors	A	pKd	6.48	6.48	6.48	ChEMBL
β₂	ADRB2	Bovine	Adrenoceptors	A	pKi	6.96	6.96	6.96	ChEMBL
β₂	ADRB2	Guinea pig	Adrenoceptors	A	pKd	7.60	7.67	7.75	ChEMBL
β₂	ADRB2	Human	Adrenoceptors	A	pKi	6.17	6.89	8.61	ChEMBL
β₂	ADRB2	Human	Adrenoceptors	A	pKd	6.13	6.73	7.30	ChEMBL
β₂	ADRB2	Human	Adrenoceptors	A	pKi	5.55	6.19	7.34	PDSP Ki database
β₂	ADRB2	Guinea pig	Adrenoceptors	A	pKi	6.49	6.73	6.97	PDSP Ki database
β₂	ADRB2	Bovine	Adrenoceptors	A	pKd	8.19	8.19	8.19	Drug Central
β₂	ADRB2	Golden hamster	Adrenoceptors	A	pKi	8.16	8.16	8.16	Drug Central
β₃	ADRB3	Human	Adrenoceptors	A	pKi	5.10	5.65	6.20	Guide to Pharmacology

Showing 1 to 20 of 32 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

β₁	ADRB1	Human	Adrenoceptors	A	pEC50	8.60	8.60	8.60	Guide to Pharmacology
β₁	ADRB1	Rat	Adrenoceptors	A	pIC50	6.22	7.25	8.28	ChEMBL
β₁	B0FL73	Guinea pig	Adrenoceptors	A	pEC50	8.22	8.22	8.22	ChEMBL
β₁	ADRB1	Human	Adrenoceptors	A	pEC50	7.00	8.80	10.08	ChEMBL
β₁	ADRB1	Human	Adrenoceptors	A	pIC50	6.48	6.48	6.48	ChEMBL
β₁	ADRB1	Human	Adrenoceptors	A	pEC50	8.05	8.05	8.05	Drug Central
β₁	ADRB1	Rat	Adrenoceptors	A	pIC50	8.21	8.21	8.21	Drug Central
β₂	ADRB2	Human	Adrenoceptors	A	pEC50	8.20	8.20	8.20	Guide to Pharmacology
β₂	ADRB2	Rat	Adrenoceptors	A	pIC50	10.00	10.00	10.00	ChEMBL
β₂	ADRB2	Dog	Adrenoceptors	A	pIC50	6.00	8.67	10.00	ChEMBL
β₂	ADRB2	Guinea pig	Adrenoceptors	A	pEC50	7.24	7.56	8.10	ChEMBL
β₂	ADRB2	Human	Adrenoceptors	A	pEC50	6.00	8.12	10.26	ChEMBL
β₂	ADRB2	Human	Adrenoceptors	A	pIC50	6.61	6.61	6.61	ChEMBL
β₂	ADRB2	Human	Adrenoceptors	A	pEC50	8.01	8.01	8.01	Drug Central
β₂	ADRB2	Guinea pig	Adrenoceptors	A	pEC50	8.12	8.12	8.12	Drug Central
β₂	ADRB2	Dog	Adrenoceptors	A	pIC50	8.22	8.22	8.22	Drug Central
β₃	ADRB3	Human	Adrenoceptors	A	pEC50	7.40	7.40	7.40	Guide to Pharmacology
β₃	ADRB3	Rat	Adrenoceptors	A	pEC50	7.06	7.47	7.89	ChEMBL
β₃	ADRB3	Human	Adrenoceptors	A	pEC50	6.00	7.82	9.01	ChEMBL
β₃	ADRB3	Human	Adrenoceptors	A	pEC50	8.07	8.07	8.07	Drug Central

Showing 1 to 20 of 72 entries

isoprenaline

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Clinical Trials

Phase I 3

Phase II 6

Phase III 0

Approved Yes

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central PubChem GPCRdb
Ligand site mutations	β₁ β₂ β₃

Sankey plot

Drug Information

Search:

Target					Disease				Phase

Gene	Protein	Receptor family	Ligand type	Class	Indication name	ICD11	ATC	Association score	Phase	Approved

ADRB1	β₁-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Asthma	CA23		0.598	4	Yes
ADRB1	β₁-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Atrial fibrillation, unspecified	BC81.3Z		0.605	2	Yes
ADRB1	β₁-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Calculus of kidney, unspecified	GB70.0Z		0.074	2	Yes
ADRB1	β₁-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Diseases of the circulatory system, unspecified	BE2Z		0.698	4	Yes
ADRB1	β₁-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Lipoma, unspecified site	2E80.0Z		0.037	1	Yes
ADRB2	β₂-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Asthma	CA23		0.612	4	Yes
ADRB2	β₂-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Atrial fibrillation, unspecified	BC81.3Z		0.598	2	Yes
ADRB2	β₂-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Calculus of kidney, unspecified	GB70.0Z		0.074	2	Yes
ADRB2	β₂-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Diseases of the circulatory system, unspecified	BE2Z		0.594	4	Yes
ADRB2	β₂-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Lipoma, unspecified site	2E80.0Z		0.037	1	Yes
ADRB3	β₃-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Asthma	CA23		0.598	4	Yes
ADRB3	β₃-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Atrial fibrillation, unspecified	BC81.3Z		0.490	2	Yes
ADRB3	β₃-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Calculus of kidney, unspecified	GB70.0Z		0.495	2	Yes
ADRB3	β₃-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Diseases of the circulatory system, unspecified	BE2Z		0.572	4	Yes
ADRB3	β₃-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Lipoma, unspecified site	2E80.0Z		0.037	1	Yes

Showing 1 to 15 of 15 entries

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isoprenaline

isoprenaline

Chemical Properties

Database connections

Bioactivities

isoprenaline

Drug properties

Clinical Trials

Database connections

Sankey plot

Drug Information