DIMENHYDRINATE


SMILES CN(C)CCOC(c1ccccc1)c1ccccc1.Cn1c(=O)c2[nH]c(Cl)nc2n(C)c1=O
InChIKey NFLLKCVHYJRNRH-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 7
Hydrogen bond donors 1
Rotatable bonds 6
Molecular weight (Da) 469.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
α1D ADA1D Human Adrenoceptors A pKi 5.85 5.85 5.85 ChEMBL
α2B ADA2B Human Adrenoceptors A pKi 5.6 5.6 5.6 ChEMBL
M5 ACM5 Human Acetylcholine (muscarinic) A pKi 6.64 6.64 6.64 ChEMBL
M4 ACM4 Human Acetylcholine (muscarinic) A pKi 7.1 7.1 7.1 ChEMBL
H1 HRH1 Human Histamine A pKi 7.43 7.43 7.43 ChEMBL
M3 ACM3 Human Acetylcholine (muscarinic) A pKi 7.02 7.02 7.02 ChEMBL
α2A ADA2A Human Adrenoceptors A pKi 5.79 5.79 5.79 ChEMBL
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 5.96 5.96 5.96 ChEMBL
M2 ACM2 Human Acetylcholine (muscarinic) A pKi 6.79 6.79 6.79 ChEMBL
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 6.48 6.48 6.48 ChEMBL
M1 ACM1 Human Acetylcholine (muscarinic) A pKi 6.96 6.96 6.96 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 6.7 6.7 6.7 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
α1D ADA1D Human Adrenoceptors A pIC50 5.54 5.54 5.54 ChEMBL
α2B ADA2B Human Adrenoceptors A pIC50 5.26 5.26 5.26 ChEMBL
M5 ACM5 Human Acetylcholine (muscarinic) A pIC50 6.5 6.5 6.5 ChEMBL
M4 ACM4 Human Acetylcholine (muscarinic) A pIC50 6.24 6.24 6.24 ChEMBL
H1 HRH1 Human Histamine A pIC50 6.5 6.5 6.5 ChEMBL
M3 ACM3 Human Acetylcholine (muscarinic) A pIC50 6.35 6.35 6.35 ChEMBL
α2A ADA2A Human Adrenoceptors A pIC50 5.37 5.37 5.37 ChEMBL
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pIC50 5.76 5.76 5.76 ChEMBL
M2 ACM2 Human Acetylcholine (muscarinic) A pIC50 6.34 6.34 6.34 ChEMBL
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pIC50 6.2 6.2 6.2 ChEMBL
M1 ACM1 Human Acetylcholine (muscarinic) A pIC50 6.35 6.35 6.35 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pIC50 6.16 6.16 6.16 ChEMBL