JNJ-10397049


SMILES O=C(Nc1ccc(cc1Br)Br)N[C@H]1COC(O[C@H]1c1ccccc1)(C)C
InChIKey RBKIJGLHFFQHBE-IRXDYDNUSA-N

Chemical properties

Hydrogen bond acceptors 3
Hydrogen bond donors 2
Rotatable bonds 3
Molecular weight (Da) 482.0

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
OX1 OX1R Human Orexin A pKi 5.5 6.08 8.3 ChEMBL
OX2 OX2R Human Orexin A pKi 5.5 7.72 8.3 ChEMBL
OX1 OX1R Human Orexin A pKi 5.3 5.55 5.8 Guide to Pharmacology
OX2 OX2R Human Orexin A pKi 7.7 8.05 8.4 Guide to Pharmacology
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
OX1 OX1R Human Orexin A pKB 5.25 5.25 5.25 Guide to Pharmacology
OX2 OX2R Human Orexin A pKB 8.0 8.0 8.0 Guide to Pharmacology