JNJ-39758979


SMILES N[C@@H]1CCN(C1)c1cc(nc(n1)N)C(C)C
InChIKey COOGVHJHSCBOQT-MRVPVSSYSA-N

Chemical properties

Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 2
Molecular weight (Da) 221.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
H4 Q91ZY3 Guinea pig Histamine A pKi 6.51 6.51 6.51 ChEMBL
H4 HRH4 Mouse Histamine A pKi 8.28 8.28 8.28 ChEMBL
H4 HRH4 Mouse Histamine A pKd 8.3 8.3 8.3 ChEMBL
H4 HRH4 Human Histamine A pKi 7.9 7.91 7.92 ChEMBL
H4 HRH4 Human Histamine A pKd 7.9 7.9 7.9 ChEMBL
H1 HRH1 Human Histamine A pKi 6.0 6.0 6.0 Guide to Pharmacology
H2 HRH2 Human Histamine A pKi 6.0 6.0 6.0 Guide to Pharmacology
H3 HRH3 Human Histamine A pKi 5.98 5.98 5.98 ChEMBL
H3 HRH3 Human Histamine A pKi 6.0 6.0 6.0 Guide to Pharmacology
H4 HRH4 Human Histamine A pKi 7.9 7.9 7.9 Guide to Pharmacology
H4 HRH4 Rat Histamine A pKi 6.73 6.73 6.73 ChEMBL
H4 HRH4 Rat Histamine A pKd 7.2 7.2 7.2 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
H4 HRH4 Mouse Histamine A pIC50 8.1 8.1 8.1 ChEMBL