JNJ 7777120


SMILES CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl
InChIKey HUQJRYMLJBBEDO-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 1
Molecular weight (Da) 277.1

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Ligand site mutations H4

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
H1 HRH1 Guinea pig Histamine A pKd 5.8 5.96 6.11 ChEMBL
H4 HRH4 Human Histamine A pKi 6.4 7.86 8.48 ChEMBL
H4 HRH4 Human Histamine A pKd 8.0 8.16 8.4 ChEMBL
H1 HRH1 Human Histamine A pKi 4.33 5.17 6.01 ChEMBL
H4 HRH4 Rat Histamine A pKi 8.22 8.45 8.62 ChEMBL
H3 HRH3 Human Histamine A pKi 4.82 5.4 5.7 ChEMBL
H4 HRH4 Human Histamine A pKd 8.4 8.4 8.4 Guide to Pharmacology
H4 HRH4 Human Histamine A pKi 7.8 8.05 8.3 Guide to Pharmacology
H4 HRH4 Mouse Histamine A pKi 6.9 7.75 8.41 ChEMBL
H3 HRH3 Rat Histamine A pKi 5.84 5.86 5.88 ChEMBL
H4 Q91ZY3 Guinea pig Histamine A pKi 5.97 5.97 5.97 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
H4 HRH4 Human Histamine A pIC50 6.66 7.28 8.28 ChEMBL
H4 HRH4 Human Histamine A pEC50 7.6 7.77 7.9 ChEMBL
H4 HRH4 Rat Histamine A pEC50 6.13 7.36 8.59 ChEMBL
H3 HRH3 Human Histamine A pEC50 6.0 6.0 6.0 ChEMBL
H4 HRH4 Mouse Histamine A pEC50 6.1 7.36 8.62 ChEMBL
H4 HRH4 Mouse Histamine A pIC50 7.4 7.4 7.4 ChEMBL