Biased Signaling Atlas

Aminophylline

Agent/drug
Bioactivity

Aminophylline

SMILES	Cn1c(=O)c2[nH]cnc2n(C)c1=O.Cn1c(=O)c2[nH]cnc2n(C)c1=O.NCCN
InChIKey	FQPFAHBPWDRTLU-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	12
Hydrogen bond donors	4
Rotatable bonds	1
Molecular weight (Da)	420.2

Database connections

PubChem ChEMBL_compound_ids DrugBank PubChem GPCRdb
Ligand site mutations	A₁

No bioactivity data available.

Aminophylline

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Clinical Trials

Phase I 4

Phase II 16

Phase III 16

Approved Yes

Database connections

PubChem ChEMBL_compound_ids DrugBank PubChem GPCRdb
Ligand site mutations	A₁

Sankey plot

Drug Information

Search:

Target					Disease				Phase

Gene	Protein	Receptor family	Ligand type	Class	Indication name	ICD11	ATC	Association score	Phase	Approved

AA1R	A₁ receptor	Adenosine receptors	Nucleotide receptors	Class A	Acute kidney failure, stage unspecified	GB60.Z		0.516	3	Yes
AA1R	A₁ receptor	Adenosine receptors	Nucleotide receptors	Class A	Asthma	CA23		0.699	4	Yes
AA1R	A₁ receptor	Adenosine receptors	Nucleotide receptors	Class A	Cardiac arrest, unspecified	MC82.Z		0.095	2	Yes
AA1R	A₁ receptor	Adenosine receptors	Nucleotide receptors	Class A	Chronic bronchitis, unspecified	CA20.1Z		0.462	4	Yes
AA1R	A₁ receptor	Adenosine receptors	Nucleotide receptors	Class A	Chronic obstructive pulmonary disease, unspecified	CA22.Z		0.566	4	Yes
AA1R	A₁ receptor	Adenosine receptors	Nucleotide receptors	Class A	Depressive disorders, unspecified	6A7Z		0.018	1	Yes
AA1R	A₁ receptor	Adenosine receptors	Nucleotide receptors	Class A	Diseases of the urinary system, unspecified	GC2Z		0.074	2	Yes
AA1R	A₁ receptor	Adenosine receptors	Nucleotide receptors	Class A	Headache, not elsewhere classified	MB4D		0.549	3	Yes
AA1R	A₁ receptor	Adenosine receptors	Nucleotide receptors	Class A	Leukaemia, unspecified	2B33.4		0.083	2	Yes
AA1R	A₁ receptor	Adenosine receptors	Nucleotide receptors	Class A	Other specified effects of air pressure or water pressure	NF04.Y		0.091	3	Yes
AA1R	A₁ receptor	Adenosine receptors	Nucleotide receptors	Class A	Pseudohypoparathyroidism	5A50.1		0.099	2	Yes
AA1R	A₁ receptor	Adenosine receptors	Nucleotide receptors	Class A	Respiratory failure	CB41		0.259	3	Yes
AA2AR	A_2A receptor	Adenosine receptors	Nucleotide receptors	Class A	Acute kidney failure, stage unspecified	GB60.Z		0.516	3	Yes
AA2AR	A_2A receptor	Adenosine receptors	Nucleotide receptors	Class A	Asthma	CA23		0.602	4	Yes
AA2AR	A_2A receptor	Adenosine receptors	Nucleotide receptors	Class A	Cardiac arrest, unspecified	MC82.Z		0.096	2	Yes
AA2AR	A_2A receptor	Adenosine receptors	Nucleotide receptors	Class A	Chronic bronchitis, unspecified	CA20.1Z		0.462	4	Yes
AA2AR	A_2A receptor	Adenosine receptors	Nucleotide receptors	Class A	Chronic obstructive pulmonary disease, unspecified	CA22.Z		0.552	4	Yes
AA2AR	A_2A receptor	Adenosine receptors	Nucleotide receptors	Class A	Depressive disorders, unspecified	6A7Z		0.048	1	Yes
AA2AR	A_2A receptor	Adenosine receptors	Nucleotide receptors	Class A	Diseases of the urinary system, unspecified	GC2Z		0.039	2	Yes
AA2AR	A_2A receptor	Adenosine receptors	Nucleotide receptors	Class A	Headache, not elsewhere classified	MB4D		0.551	3	Yes

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Main reference

Aminophylline

Aminophylline

Chemical Properties

Database connections

No bioactivity data available.

Aminophylline

Drug properties

Clinical Trials

Database connections

Sankey plot

Drug Information