Biased Signaling Atlas

lisdexamfetamine

Agent/drug
Bioactivity

lisdexamfetamine

SMILES	CC(Cc1ccccc1)NC(=O)C(N)CCCCN
InChIKey	VOBHXZCDAVEXEY-JSGCOSHPSA-N

Chemical Properties

Hydrogen bond acceptors	3
Hydrogen bond donors	3
Rotatable bonds	8
Molecular weight (Da)	263.4

Database connections

ChEMBL_compound_ids PubChem DrugBank PubChem GPCRdb

No bioactivity data available.

lisdexamfetamine

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Distribution across phases (no. indications)

Phase I 1

Phase II 4

Phase III 3

Phase IV 2

Database connections

ChEMBL_compound_ids PubChem DrugBank PubChem GPCRdb

Sankey plot

Drug Information

Search:

Target					Disease

Gene	Protein	Receptor family	Ligand type	Class	Name	Phase	ICD11	ATC	Association score

TAAR1	TA₁ receptor	Trace amine receptors	Aminergic receptors	A	Attention deficit hyperactivity disorder, presentation unspecified	4	6A05.Z	N06B	0.026
TAAR1	TA₁ receptor	Trace amine receptors	Aminergic receptors	A	Bipolar type I disorder, unspecified	3	6A60.Z	N06B	0.003
TAAR1	TA₁ receptor	Trace amine receptors	Aminergic receptors	A	Cocaine dependence, unspecified	2	6C45.2Z	N06B	0.007
TAAR1	TA₁ receptor	Trace amine receptors	Aminergic receptors	A	Multiple sclerosis, unspecified	2	8A40.Z	N06B	0.010
TAAR1	TA₁ receptor	Trace amine receptors	Aminergic receptors	A	Schizophrenia, episode unspecified	3	6A20.Z	N06B	0.405
TAAR1	TA₁ receptor	Trace amine receptors	Aminergic receptors	A	Single episode depressive disorder, severe, without psychotic symptoms	3	6A70.3	N06B	0.076

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