BURIMAMIDE
SMILES | C/N=C(\S)NCCCCc1c[nH]cn1 |
InChIKey | HXRBAVXGYZUSED-UHFFFAOYSA-N |
Chemical properties
Hydrogen bond acceptors | 2 |
Hydrogen bond donors | 3 |
Rotatable bonds | 5 |
Molecular weight (Da) | 212.1 |
Drug properties
Molecular type | Small molecule |
Physiological/Surrogate | Surrogate |
Approved drug | No |
Database connections
Bioactivities
Receptor | Activity | Source | |||||||
---|---|---|---|---|---|---|---|---|---|
GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
H3 | HRH3 | Rat | Histamine | A | pKi | 7.16 | 7.16 | 7.16 | ChEMBL |
H4 | HRH4 | Human | Histamine | A | pKi | 6.75 | 7.08 | 7.4 | ChEMBL |
H2 | HRH2 | Human | Histamine | A | pKi | 5.4 | 5.4 | 5.4 | ChEMBL |
H2 | HRH2 | Human | Histamine | A | pKd | 5.11 | 5.11 | 5.11 | ChEMBL |
H3 | HRH3 | Human | Histamine | A | pKi | 7.08 | 7.08 | 7.08 | ChEMBL |
H3 | HRH3 | Human | Histamine | A | pKd | 7.0 | 7.0 | 7.0 | ChEMBL |
H3 | HRH3 | Rat | Histamine | A | pKi | 6.66 | 7.02 | 7.32 | PDSP Ki database |
H3 | HRH3 | Human | Histamine | A | pKi | 7.08 | 7.29 | 7.9 | PDSP Ki database |
H4 | HRH4 | Human | Histamine | A | pKi | 6.74 | 7.07 | 7.4 | PDSP Ki database |
H2 | HRH2 | Human | Histamine | A | pKi | 5.4 | 6.4 | 7.4 | PDSP Ki database |
H2 | HRH2 | Guinea pig | Histamine | A | pKi | 5.52 | 5.52 | 5.52 | PDSP Ki database |
H1 | HRH1 | Rat | Histamine | A | pKi | 5.0 | 5.0 | 5.0 | PDSP Ki database |
H3 | HRH3 | Guinea pig | Histamine | A | pKd | 7.0 | 7.0 | 7.0 | ChEMBL |
Receptor | Activity | Source | |||||||
---|---|---|---|---|---|---|---|---|---|
GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
H4 | HRH4 | Human | Histamine | A | pEC50 | 7.7 | 7.7 | 7.7 | ChEMBL |