L-772,405


SMILES OC[C@@H](c1ccc(cc1)F)NC1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1
InChIKey HNKDAQNYMJNLCC-SANMLTNESA-N

Chemical properties

Hydrogen bond acceptors 6
Hydrogen bond donors 3
Rotatable bonds 9
Molecular weight (Da) 462.3

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT1D 5HT1D Human 5-Hydroxytryptamine A pKi 9.05 9.05 9.05 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT7 5HT7R Rat 5-Hydroxytryptamine A pIC50 6.27 6.27 6.27 ChEMBL
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pIC50 7.18 7.18 7.18 ChEMBL
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pIC50 7.2 7.2 7.2 Guide to Pharmacology
5-HT1B 5HT1B Human 5-Hydroxytryptamine A pIC50 6.73 6.78 6.82 ChEMBL
5-HT1B 5HT1B Human 5-Hydroxytryptamine A pIC50 6.8 6.8 6.8 Guide to Pharmacology
5-HT1D 5HT1D Human 5-Hydroxytryptamine A pEC50 8.96 9.01 9.1 ChEMBL
5-HT1D 5HT1D Human 5-Hydroxytryptamine A pIC50 9.05 9.05 9.05 ChEMBL
5-HT1D 5HT1D Human 5-Hydroxytryptamine A pIC50 9.0 9.0 9.0 Guide to Pharmacology
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pIC50 5.96 5.96 5.96 ChEMBL