lixivaptan


SMILES Fc1ccc(c(c1)C(=O)Nc1ccc(c(c1)Cl)C(=O)N1Cc2cccn2Cc2c1cccc2)C
InChIKey PPHTXRNHTVLQED-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 3
Molecular weight (Da) 473.1

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug Yes

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
V2 V2R Human Vasopressin and oxytocin A pKi 8.9 9.05 9.2 Guide to Pharmacology
V2 V2R Human Vasopressin and oxytocin A pKi 7.05 7.78 8.64 ChEMBL
V1A V1AR Human Vasopressin and oxytocin A pKi 5.22 6.29 7.36 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
V1A V1AR Rat Vasopressin and oxytocin A pIC50 6.39 6.6 7.09 ChEMBL
V2 V2R Rat Vasopressin and oxytocin A pIC50 8.64 8.8 9.3 ChEMBL
V2 V2R Human Vasopressin and oxytocin A pIC50 7.04 8.42 9.0 ChEMBL
OT OXYR Human Vasopressin and oxytocin A pIC50 6.29 6.29 6.29 ChEMBL
V1A V1AR Human Vasopressin and oxytocin A pIC50 6.64 6.76 6.91 ChEMBL