LTD4


SMILES CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N
InChIKey YEESKJGWJFYOOK-LDDGIIIKSA-N

Chemical properties

Hydrogen bond acceptors 6
Hydrogen bond donors 5
Rotatable bonds 20
Molecular weight (Da) 496.3

Drug properties

Molecular type Small molecule
Physiological/Surrogate Endogenous
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
CysLT1 CLTR1 Human Leukotriene A pKd 8.0 9.37 10.7 Guide to Pharmacology
CysLT2 CLTR2 Human Leukotriene A pKd 7.3 8.35 9.4 Guide to Pharmacology
CysLT2 CLTR2 Human Leukotriene A pKi 7.3 7.7 8.1 Guide to Pharmacology
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
GPR17 GPR17 Human A orphans A pEC50 8.14 8.25 8.36 Guide to Pharmacology
GPR17 GPR17 Mouse A orphans A pEC50 9.2 9.2 9.2 Guide to Pharmacology
CysLT1 CLTR1 Human Leukotriene A pEC50 7.34 8.67 9.22 Guide to Pharmacology
CysLT1 CLTR1 Human Leukotriene A pIC50 8.05 8.05 8.05 Guide to Pharmacology
CysLT2 CLTR2 Human Leukotriene A pEC50 6.84 7.53 8.6 Guide to Pharmacology
CysLT2 CLTR2 Human Leukotriene A pIC50 7.69 7.69 7.69 Guide to Pharmacology